Department of Reproduction Gynecology, Northwest Women and Children's Hospital, Shannxi 710003, Xi'an, China
Department of Reproductive Medical center, Xi'an No. 4 Hospital, Shannxi 710004, Xi'an, China.
Biosci Rep. 2018 Sep 13;38(5). doi: 10.1042/BSR20181071. Print 2018 Oct 31.
Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the etiology of cancer. Several case-control studies have been conducted to assess the association of -174G>C (rs1800795) polymorphism with the risk of cervical cancer, yet with conflicting conclusions. To derive a more precise estimation of the relationship, we performed this meta-analysis updated to June 2018. A total of seven original publications were identified covering -174G>C (rs1800795) polymorphism. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship strengths. Statistically significant relationship was observed between -174G>C polymorphism and cervical cancer risk (OR = 0.61, 95% CI: 0.40-0.94 for GG vs. CC, and OR = 0.77, 95% CI: 0.64-0.93 for G vs. C). Moreover, the significant association was found among Asians (OR = 0.46, 95% CI: 0.29-0.75 for GG vs. CC, and OR = 0.70, 95% CI: 0.57-0.89 for G vs. C); hospital-based subgroup (OR = 0.53, 95% CI: 0.38-0.72 for GG vs. CC, and OR = 0.73, 95% CI: 0.61-0.87 for G vs. C); and Hardy-Weinberg equilibrium ≤0.05 (OR = 0.56, 95% CI: 0.37-0.86 for GG vs. GC, and OR = 0.66, 95% CI: 0.47-0.93 for G vs. C). This meta-analysis showed the evidence that the -174G>C polymorphism was a low-penetrance susceptibility variant for cervical cancer. Further large-scale case-control studies are needed to confirm these results.
白细胞介素-6 (IL-6) 是一种多功能细胞因子，与癌症的病因有关。已经进行了几项病例对照研究来评估 -174G>C（rs1800795）多态性与宫颈癌风险之间的关联，但结论存在矛盾。为了更准确地评估这种关系，我们进行了这项荟萃分析，并更新至 2018 年 6 月。共确定了 7 项原始出版物，涵盖了 -174G>C（rs1800795）多态性。使用比值比（OR）和 95%置信区间（CI）来评估关系强度。统计学上观察到 -174G>C 多态性与宫颈癌风险之间存在显著关联（OR=0.61，95%CI：0.40-0.94，GG 与 CC 相比，和 OR=0.77，95%CI：0.64-0.93，G 与 C 相比）。此外，在亚洲人群中发现了显著的相关性（OR=0.46，95%CI：0.29-0.75，GG 与 CC 相比，和 OR=0.70，95%CI：0.57-0.89，G 与 C 相比）；基于医院的亚组（OR=0.53，95%CI：0.38-0.72，GG 与 CC 相比，和 OR=0.73，95%CI：0.61-0.87，G 与 C 相比）；和 Hardy-Weinberg 平衡≤0.05（OR=0.56，95%CI：0.37-0.86，GG 与 GC 相比，和 OR=0.66，95%CI：0.47-0.93，G 与 C 相比）。这项荟萃分析表明，-174G>C 多态性是宫颈癌的低外显率易感变异。需要进一步进行大规模的病例对照研究来证实这些结果。
