Ren Honggang, Zhang Yue, Yao Yonghua, Guo Tao, Wang Huafang, Mei Heng, Hu Yu
Institute of Hematology, Union Hospital Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Department of Hematology, Shidong Hospital, Yangpu District, Shanghai, P.R. China.
Medicine (Baltimore). 2016 Jul;95(27):e4030. doi: 10.1097/MD.0000000000004030.
Studies investigating the association between interleukin-6 (IL-6) gene-174 G/C polymorphism (rs1800795) and thrombosis disorder risk reported conflicting results. The aim of our study was to assess the association between the IL-6 gene 174 G/C polymorphisms and the risk of thrombosis disorders.Thirty four case-control studies in 29 articles with 29,865 individuals were incorporated in this meta-analysis by searching the public databases including Medline, Embase, and ISI Web of Science databases as of June 1st, 2015. The odds ratio (OR) and 95% confidence interval (95%CI) were used to assess the strength of the association.By pooling all studies, there was marginal association between and the risk of thrombotic disorders (1.09[0.97-1.22]), arterial thrombotic disorders (1.08[0.95-1.23]), and myocardial infarction (MI, 1.14[0.99-1.32]) under dominant genetic effect (C carriers vs GG). In subgroup analyses stratified by ethnicity, study scale, thrombotic category, and country, the results indicated that IL-6 gene-174 G/C polymorphism was significantly associated with increased risk of thrombotic disorders given the conditional such as Asians, large sample-sized, MI, population-based, and Indian studies (C carriers vs GG: 1.39 [1.13-1.72] and C allele vs G allele: 1.36 [1.18-1.56] for Asian; C carriers vs GG: 1.15 [1.01-1.31] and C allele vs G allele: 1.12 [1.01-1.23] for large sample-sized studies; C allele vs G allele: 1.10 [1.03-1.18] for population-based studies; and C carriers vs GG: 1.40 [1.19-1.65] for Indian studies). We did not observe significant association between IL-6-174 G/C and the risk of Caucasians, small sample-sized studies, stroke and venous studies, and other country studies.This meta-analysis suggests that IL-6 gene-174 G/C polymorphism may be marginally associated with risk of thrombotic disorders, arterial disorders, MI especially for Asian, Indian, population-based, and large sample-sized studies. More studies with larger sample size and well-designed studies might be warranted.
研究白细胞介素-6（IL-6）基因-174G/C多态性（rs1800795）与血栓形成疾病风险之间关联的研究报告了相互矛盾的结果。我们研究的目的是评估IL-6基因174G/C多态性与血栓形成疾病风险之间的关联。通过检索截至2015年6月1日的包括Medline、Embase和ISI Web of Science数据库在内的公共数据库，纳入了29篇文章中的34项病例对照研究，涉及29865名个体。采用比值比（OR）和95%置信区间（95%CI）来评估关联强度。通过汇总所有研究，在显性遗传效应（C携带者与GG相比）下，与血栓形成疾病风险（1.09[0.97 - 1.22]）、动脉血栓形成疾病（1.08[0.95 - 1.23]）和心肌梗死（MI，1.14[0.99 - 1.32]）之间存在微弱关联。在按种族、研究规模、血栓形成类别和国家分层的亚组分析中，结果表明，在亚洲人、大样本量、心肌梗死、基于人群和印度的研究等条件下，IL-6基因-174G/C多态性与血栓形成疾病风险增加显著相关（亚洲人：C携带者与GG相比为1.39[1.13 - 1.72]，C等位基因与G等位基因相比为1.36[1.18 - 1.56]；大样本量研究：C携带者与GG相比为1.15[1.01 - 1.31]，C等位基因与G等位基因相比为1.12[1.01 - 1.23]；基于人群的研究：C等位基因与G等位基因相比为1.10[1.03 - 1.18]；印度的研究：C携带者与GG相比为1.40[1.19 - 1.65]）。我们未观察到IL-6 - 174G/C与白种人、小样本量研究、中风和静脉研究以及其他国家研究的风险之间存在显著关联。这项荟萃分析表明，IL-6基因-174G/C多态性可能与血栓形成疾病、动脉疾病、心肌梗死风险存在微弱关联，特别是对于亚洲、印度、基于人群和大样本量的研究。可能需要更多样本量更大且设计良好的研究。
