Orrom W J, Brzezinski W S, Wiens E W
Division of Colon and Rectal Surgery, University of Alberta, Edmonton, Canada.
Dis Colon Rectum. 1990 Jun;33(6):490-3. doi: 10.1007/BF02052144.
The frequency of colorectal neoplasia was assessed through colonoscopy in 114 patients with a family history of colorectal cancer. In over 90 percent of patients, a first-degree relative was affected. Twenty-one percent of patients who were studied endoscopically were positive for neoplastic disease, including two invasive cancers. Twenty-eight percent of patients had adenomas beyond the splenic flexure. Multiple primary relatives further increased risk with 36 percent positive for neoplasia. Neoplasia was common in young patients, with 25 percent under the age of 40 years positive for adenomas. These findings are identical to recent pedigree studies and further support a genetic basis for common colorectal cancers. First-degree relatives of patients with colorectal cancer should be considered at high-risk for colorectal neoplasia. Screening and surveillance with colonoscopy is recommended.
通过结肠镜检查对114例有结直肠癌家族史的患者进行了结直肠肿瘤发生频率的评估。超过90%的患者有一级亲属患病。接受内镜检查的患者中有21%患有肿瘤性疾病，包括2例浸润性癌。28%的患者在脾曲以远有腺瘤。多个原发性亲属进一步增加了风险，36%的患者有肿瘤形成。肿瘤形成在年轻患者中很常见，25%年龄在40岁以下的患者腺瘤呈阳性。这些发现与最近的系谱研究一致，并进一步支持常见结直肠癌的遗传基础。结直肠癌患者的一级亲属应被视为结直肠肿瘤的高危人群。建议进行结肠镜检查筛查和监测。
