高密度脂蛋白胆固醇对严重冠状动脉疾病人群冠状动脉侧支循环形成的影响。

Influence of high-density lipoprotein cholesterol on coronary collateral formation in a population with significant coronary artery disease.

作者信息

Hsu Po-Chao, Su Ho-Ming, Juo Suh-Hang, Yen Hsueh-Wei, Voon Wen-Chol, Lai Wen-Ter, Sheu Sheng-Hsiung, Lin Tsung-Hsien

机构信息

Department of Internal Medicine, Division of Cardiology, Kaohsiung Medical University, 100 Tzyou 1st Road, Kaohsiung, 80708, Taiwan, ROC.

出版信息

BMC Res Notes. 2013 Mar 20;6:105. doi: 10.1186/1756-0500-6-105.

DOI:10.1186/1756-0500-6-105

PMID:23510196

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3606844/

Abstract

BACKGROUND

Coronary collateral circulation plays an important role in protecting myocardium from ischemia and reducing cardiovascular events. Low High-density lipoprotein cholesterol (HDL-C) level is a strong risk factor for coronary artery disease (CAD) and is associated with poor cardiovascular outcome. It was recently reported to be associated with poor coronary collateral development in Turkish population. Hence, we investigated the influence of HDL-C on coronary collateral formation in Chinese population.

METHODS

We evaluated 970 consecutive patients undergoing coronary angiography, and 501 patients with significant coronary artery disease (SCAD) were finally analyzed. The collateral scoring system developed by Rentrop was used to classify patient groups as those with poor or good collaterals.

RESULTS

The patients with poor collaterals had fewer diseased vessels (1.97 ± 0.84 vs 2.47 ± 0.68, p < 0.001) and lower diffuse score (2.65 ± 1.63 vs 3.76 ± 1.78, p < 0.001). There was no significant difference in HDL-C and other variables between good and poor collaterals. Multivariate analysis showed only number of diseased vessels (odd ratio 0.411, p < 0.001) was a significant predictor of poor collateral development.

CONCLUSIONS

The extent of CAD severity but not HDL-C level was the most powerful predictor of coronary collateral formation in our Chinese population with SCAD.

摘要

背景

冠状动脉侧支循环在保护心肌免受缺血影响和减少心血管事件方面发挥着重要作用。低高密度脂蛋白胆固醇（HDL-C）水平是冠状动脉疾病（CAD）的一个强有力的危险因素，并且与不良心血管结局相关。最近有报道称，在土耳其人群中，它与冠状动脉侧支发育不良有关。因此，我们研究了HDL-C对中国人群冠状动脉侧支形成的影响。

方法

我们评估了970例连续接受冠状动脉造影的患者，最终分析了501例患有严重冠状动脉疾病（SCAD）的患者。采用Rentrop开发的侧支评分系统将患者组分为侧支不良或良好的患者。

结果

侧支不良的患者病变血管较少（1.97±0.84对2.47±0.68，p<0.001），弥漫性评分较低（2.65±1.63对3.76±1.78，p<0.001）。HDL-C和其他变量在侧支良好和不良的患者之间没有显著差异。多变量分析显示，只有病变血管数量（比值比0.411，p<0.001）是侧支发育不良的显著预测因素。