Zhang Chunjing, Han Chunchao, Zhao Baosheng, Yu Haitao
Department of Biochemistry and Molecular Biology, Qiqihar Medical University, Qiqihar Heilongjiang, People's Republic of China.
Int J Med Mushrooms. 2012;14(6):557-61. doi: 10.1615/intjmedmushr.v14.i6.30.
Culinary-medicinal Royal Sun mushroom, Agaricus brasiliensis (AbS), has traditionally been used for the prevention of a range of diseases, including cancer, hepatitis, atherosclerosis, hypercholesterolemia, diabetes, and dermatitis. The hepatoprotective effect of the fermented mushroom of A. brasiliensis (FMAE) and wild-growing A. brasiliensis (WMAE) were studied in this paper. An in vivo study of carbon tetrachloride (CCl4)-induced antioxidant activity in 2-month-old rats was conducted by examining the levels of activities of alanine aminotransaminase (ALT) and aspartate aminotransaminase (AST) and the antioxidant enzymes, including glutathione peroxidase (GSHPx) and catalase (CAT). Rats were divided into four groups, each containing six rats. The first group served as a control group. The second group was the CCl4 group. Group I and group II were treated orally with distilled water for 14 days respectively. Group III and Group IV were treated orally by WMAE and FMAE at oral doses of 50 mg/kg-day, respectively. Both WMAE and FMAE could reduce CCl4-induced toxicity, particularly hepatotoxicity, by suppressing ALT and AST activities, and increasing antioxidant enzyme activity. The studies demonstrate that both the fermented and wild-growing A. brasiliensis could protect the liver against CCl4-induced oxidative damage in rats.
食用兼药用的巴西蘑菇（AbS），传统上一直被用于预防一系列疾病，包括癌症、肝炎、动脉粥样硬化、高胆固醇血症、糖尿病和皮炎。本文研究了巴西蘑菇发酵物（FMAE）和野生巴西蘑菇（WMAE）的肝脏保护作用。通过检测丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）的活性水平以及抗氧化酶，包括谷胱甘肽过氧化物酶（GSHPx）和过氧化氢酶（CAT），对2月龄大鼠进行了四氯化碳（CCl4）诱导的抗氧化活性的体内研究。大鼠被分为四组，每组六只。第一组作为对照组。第二组是CCl4组。第一组和第二组分别用蒸馏水口服给药14天。第三组和第四组分别以50毫克/千克·天的口服剂量用WMAE和FMAE进行口服治疗。WMAE和FMAE均可通过抑制ALT和AST活性并增加抗氧化酶活性来降低CCl4诱导的毒性，特别是肝毒性。研究表明，发酵的和野生的巴西蘑菇均可保护大鼠肝脏免受CCl4诱导的氧化损伤。
