Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Mol Immunol. 2013 Oct;55(3-4):424-8. doi: 10.1016/j.molimm.2013.02.007. Epub 2013 Mar 16.
Inflammation plays an essential role in the development and progression of atherosclerotic lesions. The major histocompatibility complex class II trans-activator (MHC2TA) is considered an important molecule in the inflammatory process regulation. The aim of the present study was to evaluate the role of MHC2TA gene polymorphisms as susceptibility markers for acute coronary syndrome (ACS).
Three polymorphisms (-168 A>G, 1614 C>G, and 2536 G>A) of the MHC2TA gene were analyzed by 5' exonuclease TaqMan genotyping assays in a group of 297 patients with ACS and 283 healthy controls. Haplotypes were constructed after linkage disequilibrium analysis.
The 1614 C allele and CC genotype were associated with risk of developing ACS (PC=0.014, OR=1.37 and PC=0.006, OR=1.90, respectively). Based on Hosmer-Lemeshow Goodness of Fit test, the recessive model was selected to estimate risk between ACS patients and controls adjusted by cardiovascular risk factors using a multiple logistic analysis. In this case, the OR adjusted was 1.78 for the 1614 CC genotype (P=0.023). The analysis of linkage disequilibrium showed one risk haplotype (ACG) and one protective haplotype (AGG) for developing ACS (P=0.02, OR=1.5 and P=0.04, OR=0.72, respectively).
The results suggest that MHC2TA 1614 gene polymorphism could be involved in the risk of developing ACS.
炎症在动脉粥样硬化病变的发生和发展中起着至关重要的作用。主要组织相容性复合体 II 类转录激活物（MHC2TA）被认为是炎症过程调节中的重要分子。本研究旨在评估 MHC2TA 基因多态性作为急性冠脉综合征（ACS）易感性标志物的作用。
通过 5'外切酶 TaqMan 基因分型检测法分析了 MHC2TA 基因的三个多态性（-168A>G、1614C>G 和 2536G>A），共纳入 297 例 ACS 患者和 283 例健康对照者。在连锁不平衡分析后构建单体型。
1614C 等位基因和 CC 基因型与 ACS 发病风险相关（PC=0.014，OR=1.37 和 PC=0.006，OR=1.90）。基于 Hosmer-Lemeshow 拟合优度检验，选择隐性模型来估计经心血管危险因素调整后的 ACS 患者与对照组之间的风险，使用多因素逻辑回归分析。在这种情况下，1614CC 基因型的调整 OR 为 1.78（P=0.023）。连锁不平衡分析显示，一个风险单体型（ACG）和一个保护性单体型（AGG）与 ACS 发病相关（P=0.02，OR=1.5 和 P=0.04，OR=0.72）。
结果表明，MHC2TA 1614 基因多态性可能与 ACS 的发病风险有关。
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