Kuikka J T, Länsimies E, Kuikka E O
Department of Clinical Physiology, University Central Hospital, Kuopio, Finland.
Eur J Nucl Med. 1990;16(4-6):275-83. doi: 10.1007/BF00842780.
A convection-diffusion model is applied for the determination of cerebral circulation parameters in patients with frontal lobe epilepsy. The method employs 99mTc-HMPAO, dynamic brain imaging and SPECT. The model takes into account both the capillary and cell permeabilities of HMPAO. Experiments were performed in 41 patients with epilepsy and 10 patients without evident cerebrovascular disease. The results indicate that in the inter ictal epileptic foci, cerebral blood flow was reduced (18% +/- 19%), cerebral blood volume was increased (21% +/- 14%), and the capillary permeability of HMPAO in the affected side was on the average 50% of the value in the contralateral side, whereas the reflux from brain tissue to blood was increased. These findings mean that HMPAO diffusion across the blood brain barrier is restricted and HMPAO slackly interacts with the intra cellular component of the inter ictal epileptic foci.
采用对流扩散模型来测定额叶癫痫患者的脑循环参数。该方法使用99mTc-HMPAO、动态脑成像和单光子发射计算机断层扫描（SPECT）。该模型同时考虑了HMPAO的毛细血管通透性和细胞通透性。对41例癫痫患者和10例无明显脑血管疾病的患者进行了实验。结果表明，在发作间期癫痫病灶中，脑血流量减少（18%±19%），脑血容量增加（21%±14%），患侧HMPAO的毛细血管通透性平均为对侧的50%，而从脑组织到血液的回流增加。这些发现意味着HMPAO跨血脑屏障的扩散受到限制，且HMPAO与发作间期癫痫病灶的细胞内成分相互作用较弱。
