Henze E, Huang S C, Ratib O, Hoffman E, Phelps M E, Schelbert H R
J Nucl Med. 1983 Nov;24(11):987-96.
Quantification of myocardial tissue kinetics from serial tomographic images is limited because of bidirectional cross-contamination of recorded counts between myocardium and blood for metabolic tracers with relative slow blood clearance. We have developed and validated a new deconvolution technique that permits calculation of spillover fractions derived from geometric measurements of the imaged cross section (wall thickness, chamber diameter) and the intrinsic resolution of the tomograph. Serial gated positron-emission computerized imaging (PCT) and a-v blood sampling across the heart were performed in five dogs for 45 min after i.v. C-11 palmitate (CPA) and in five dogs for 3 hr after i.v. F-18 deoxyglucose (FDG). Tracer concentrations in myocardial tissue and arterial blood were also measured in vitro. Uncorrected PCT tissue and blood concentrations correlated poorly with in vitro measurements. After correction for count crossover, the correlation for FDG in tissue was r = 0.99, for FDG in blood r = 0.97, and for CPA in blood r = 0.99. Deconvolution techniques applied to serial PCT images provide accurate noninvasive measurement of myocardial tracer concentrations and direct determination of the arterial input function required for measurements of myocardial metabolism.
由于代谢示踪剂血液清除相对缓慢，心肌和血液之间记录计数存在双向交叉污染，因此从连续断层图像定量心肌组织动力学受到限制。我们开发并验证了一种新的反卷积技术，该技术允许根据成像横截面的几何测量值（壁厚、腔直径）和断层扫描仪的固有分辨率计算溢出分数。在五只狗静脉注射C-11棕榈酸酯（CPA）后45分钟以及五只狗静脉注射F-18脱氧葡萄糖（FDG）后3小时内，进行了连续门控正电子发射计算机成像（PCT）和心脏全层动静脉血采样。还在体外测量了心肌组织和动脉血中的示踪剂浓度。未经校正的PCT组织和血液浓度与体外测量值相关性较差。在校正计数交叉后，组织中FDG的相关性为r = 0.99，血液中FDG的相关性为r = 0.97，血液中CPA的相关性为r = 0.99。应用于连续PCT图像的反卷积技术可提供心肌示踪剂浓度的准确无创测量，并直接确定心肌代谢测量所需的动脉输入函数。
