Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescent, 119260 (Singapore).
Chem Asian J. 2013 May;8(5):858-71. doi: 10.1002/asia.201201236. Epub 2013 Mar 19.
In the past few years, highly luminescent noble metal nanoclusters (e.g., Au and Ag NCs or Au/Ag NCs in short) have emerged as a class of promising optical probes for the construction of high-performance optical sensors because of their ultrasmall size (<2 nm), strong luminescence, good photostability, excellent biocompatibility, and unique metal-core@ligand-shell structure. In this Focus Review, we briefly summarize the common syntheses for water-soluble highly-luminescent thiolate- and protein-protected Au/Ag NCs and their interesting luminescence properties, highlight recent progress in their use as optical sensors with an emphasis on the mechanisms underlying their selectivity, and finally discuss approaches to improving their sensitivity. The scope of the works surveyed is confined to highly luminescent thiolate- and protein-protected Au/Ag NCs.
在过去的几年中，由于具有超小尺寸(<2nm)、强发光、良好的光稳定性、优异的生物相容性和独特的金属核@配体壳结构，高发光贵金属纳米团簇（例如，金和银纳米团簇或简称 Au/Ag NCs）已成为一类很有前途的光学探针，用于构建高性能光学传感器。在本重点综述中，我们简要总结了水溶性高发光硫醇和蛋白质保护的 Au/Ag NCs 的常见合成方法及其有趣的发光性质，重点介绍了它们作为光学传感器的最新进展，重点讨论了其选择性的机制，并最后讨论了提高其灵敏度的方法。综述的工作范围仅限于高发光硫醇和蛋白质保护的 Au/Ag NCs。
