Bernard Jessica A, Peltier Scott J, Benson Bryan L, Wiggins Jillian Lee, Jaeggi Susanne M, Buschkuehl Martin, Jonides John, Monk Christopher S, Seidler Rachael D
Department of Psychology.
Functional MRI Laboratory.
Cereb Cortex. 2014 Aug;24(8):2151-9. doi: 10.1093/cercor/bht065. Epub 2013 Mar 19.
The cerebellar dentate nucleus has been reported to project to motor and prefrontal cortical regions in nonhuman primates from 2 anatomically distinct areas. However, despite a wealth of human neuroimaging data implicating the cerebellum in motor and cognitive behaviors, evidence of dissociable motor and cognitive networks comprising the human dentate is lacking. To investigate the existence of these 2 networks in the human brain, we used resting-state functional connectivity magnetic resonance imaging. The resting-state fMRI signal was extracted from regions of interest in the dorsal and ventral dentate nucleus. We report a "motor" network involving the dorsal dentate, anterior regions of the cerebellum, and the precentral gyrus, and a "cognitive" network involving the ventral dentate, Crus I, and prefrontal cortex. The existence of these 2 distinct networks supports the notion that cerebellar involvement in cognitive tasks is above and beyond that associated with motor response components.
据报道，在非人类灵长类动物中，小脑齿状核从两个解剖学上不同的区域投射到运动和前额叶皮质区域。然而，尽管大量人类神经影像学数据表明小脑参与运动和认知行为，但缺乏关于人类齿状核可分离的运动和认知网络的证据。为了研究这两个网络在人脑中的存在情况，我们使用了静息态功能连接磁共振成像。静息态功能磁共振成像信号从小脑齿状核背侧和腹侧的感兴趣区域提取。我们报告了一个涉及齿状核背侧、小脑前部区域和中央前回的“运动”网络，以及一个涉及齿状核腹侧、小脑脚I和前额叶皮质的“认知”网络。这两个不同网络的存在支持了以下观点：小脑参与认知任务的程度超出了与运动反应成分相关的程度。
