Department of Neurology, University of Duisburg-Essen, Essen, Germany.
Neuroimage. 2011 Aug 1;57(3):1184-91. doi: 10.1016/j.neuroimage.2011.05.045. Epub 2011 May 25.
There is increasing evidence of a topographic organization within the human cerebellar cortex for motor and non-motor functions. Likewise, a subdivision of the dentate nucleus in a more dorsal and rostral motor domain and a more ventral and caudal non-motor domain has been proposed by Dum and Strick (2003) based on anatomical studies in monkey. In humans, however, very little is known about topographic organization within the dentate nucleus. Activation of the dentate nucleus in a verb generation task was examined in young and healthy subjects using ultra-highfield 7T functional magnetic resonance imaging (fMRI) with its increase in signal-to-noise ratio. Data of 17 subjects were included in statistical analysis. Subjects were asked to (i) read words (nouns) aloud presented on a screen, (ii) silently read the same nouns, (iii) silently generate the appropriate verbs to the same nouns and (iv) to silently repeat the names of the months. A block design was used. For image processing, a recently developed region of interest (ROI) driven normalization method of the dentate nuclei was applied. Activation related to motor speech (contrast aloud reading minus silent reading) was strongest in the rostral parts of the dentate nucleus. Dorsorostral activations were present bilaterally. Activation related to verb generation (contrast verb generation minus silent reading) was found in the ventrocaudal parts of the dentate nucleus on the right. The present findings are in good accordance with the anatomical data in monkeys and suggest that the human dentate nucleus can be subdivided into a rostral and more dorsal motor domain and a ventrocaudal non-motor domain.
越来越多的证据表明，人类小脑皮层在运动和非运动功能方面存在着地形组织。同样，Dum 和 Strick（2003）基于猴子的解剖学研究，提出了齿状核在更背侧和更头侧的运动域以及更腹侧和更尾侧的非运动域的细分。然而，在人类中，关于齿状核内部的地形组织知之甚少。使用超高场 7T 功能磁共振成像（fMRI）及其信噪比的提高，检查了年轻人和健康受试者在动词生成任务中齿状核的激活情况。在统计分析中纳入了 17 名受试者的数据。要求受试者（i）大声朗读屏幕上显示的单词（名词），（ii）默读相同的名词，（iii）默读并生成与相同名词相对应的动词，以及（iv）默读月份的名称。采用块设计。对于图像处理，应用了最近开发的齿状核感兴趣区（ROI）驱动的归一化方法。与运动言语相关的激活（对比大声朗读减去默读）在齿状核的头侧部分最强。背侧激活存在于双侧。在右侧齿状核的腹侧和尾侧部分发现了与动词生成相关的激活（对比动词生成减去默读）。目前的发现与猴子的解剖学数据非常吻合，表明人类齿状核可以进一步细分为头侧和更背侧的运动域以及腹侧和尾侧的非运动域。
