Chaiyakulsil Chanapai, Prommalikit Olarn
Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.
J Med Assoc Thai. 2012 Dec;95 Suppl 12:S138-41.
Extended-spectrum beta-lactamase (ESBL) producing organisms cause wide spectrum of diseases including urinary tract infection, cholangitis, intra-abdominal abscess or pneumonia but rarely meningitis. The present report a successful nonsurgical, medical treatment in a child with Escherichia coli ESBL meningitis with acute symptomatic communicating hydrocephalus and ventricular empyema. Incidence of infections from ESBL producing organisms are increasingly emerging and causing wide spectrum of illnesses which prompts for both aggressive medical and surgical intervention to prevent morbidity and mortality. Antimicrobial agents must be vigilantly utilized to prevent possible development of new highly-resistant organisms.
产超广谱β-内酰胺酶(ESBL)的生物体可引发多种疾病,包括尿路感染、胆管炎、腹腔内脓肿或肺炎,但很少引起脑膜炎。本报告介绍了一例成功的非手术治疗病例,该患儿患有大肠杆菌ESBL脑膜炎,并伴有急性症状性交通性脑积水和脑室积脓。产ESBL生物体引起的感染发生率日益上升,导致多种疾病,这促使采取积极的药物和手术干预措施以预防发病和死亡。必须谨慎使用抗菌药物,以防止可能出现新的高度耐药生物体。