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嗜铬细胞瘤导致心肌病、缺血性卒中和急性动脉血栓形成:一例病例报告及文献复习

Pheochromocytoma causing cardiomyopathy, ischemic stroke and acute arterial thrombosis: a case report and review of the literature.

作者信息

Vindenes Tine, Crump Natalie, Casenas Ritche, Wood Kelly

机构信息

Department of Internal Medicine, Danbury Hospital, Danbury, CT, USA.

出版信息

Conn Med. 2013 Feb;77(2):95-8.

PMID:23513638
Abstract

Pheochromocytoma is a rare catecholamine secreting neuroendocrine tumor with an estimated annual incidence of one to four per million and prevalence among hypertensive patients of 0.1 to 0.6%. The symptoms and signs of pheochromocytoma include the classic triad of episodic headache, increased sweating, and palpitations. These are as a result of an uncontrolled release of catecholamines. There exist only a small number of reports of pheochromocytoma simulating hypertrophic obstructive cardiomyopathy, few reports of pheochromocytoma-induced ischemic stroke and only two reported cases with pheochromocytoma-induced arterial thrombosis. We present a case of multiple, rare clinical complications of pheochromocytoma occurring in the same patient and the review of literature of these complications.

摘要

嗜铬细胞瘤是一种罕见的分泌儿茶酚胺的神经内分泌肿瘤,估计年发病率为百万分之一至四,在高血压患者中的患病率为0.1%至0.6%。嗜铬细胞瘤的症状和体征包括发作性头痛、多汗和心悸这一经典三联征。这些是儿茶酚胺不受控制释放的结果。仅有少数关于嗜铬细胞瘤模拟肥厚性梗阻性心肌病的报道,关于嗜铬细胞瘤诱发缺血性卒中的报道较少,仅有两例关于嗜铬细胞瘤诱发动脉血栓形成的报道。我们报告一例同一患者发生的嗜铬细胞瘤多种罕见临床并发症的病例,并对这些并发症的文献进行综述。

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1
Pheochromocytoma causing cardiomyopathy, ischemic stroke and acute arterial thrombosis: a case report and review of the literature.嗜铬细胞瘤导致心肌病、缺血性卒中和急性动脉血栓形成:一例病例报告及文献复习
Conn Med. 2013 Feb;77(2):95-8.
2
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A case of unusual acute coronary syndrome.一起不寻常的急性冠脉综合征病例。
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[Personal experience in diagnosis and localization of pheochromocytoma].[嗜铬细胞瘤诊断与定位的个人经验]
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Stress-related cardiomyopathy, ventricular dysfunction, artery thrombosis: a hidden pheochromocytoma.应激相关心肌病、心室功能障碍、动脉血栓形成:隐匿性嗜铬细胞瘤。
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[A case of pheochromocytoma with left ventricular configuration mimicking hypertrophic obstructive cardiomyopathy].[一例具有类似肥厚型梗阻性心肌病左心室形态的嗜铬细胞瘤病例]
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A case of pheochromocytoma with secondary dilated cardiomyopathy, ventricular fibrillation and mural thrombus of left ventricle.一例嗜铬细胞瘤伴继发性扩张型心肌病、心室颤动及左心室壁血栓形成。
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Pheochromocytoma-Induced Cardiomyopathy Mimicking Acute Coronary Syndrome.嗜铬细胞瘤诱发的心肌病酷似急性冠状动脉综合征。
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Clinical imaging rounds: hypertension in a postpartum patient.临床影像病例讨论:产后患者的高血压
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引用本文的文献

1
Pheochromocytoma with two rare manifestations: Non-ST segment myocardial infarction with normal coronary arteries and blue toe syndrome.嗜铬细胞瘤伴两种罕见表现:冠状动脉正常的非ST段心肌梗死和蓝趾综合征。
SAGE Open Med Case Rep. 2025 Jul 16;13:2050313X251359723. doi: 10.1177/2050313X251359723. eCollection 2025.
2
Triad of cluster-like headaches, hypertension and hypercoagulability a pointer to pheochromocytoma.丛集性头痛、高血压和高凝状态三联征提示嗜铬细胞瘤。
BMJ Case Rep. 2024 Feb 6;17(2):e257899. doi: 10.1136/bcr-2023-257899.
3
Case report: Antiplatelet therapy on metastatic paraganglioma-associated cutaneous vascular disease and literature review.
病例报告:抗血小板治疗转移性副神经节瘤相关皮肤血管疾病及文献综述
Front Med (Lausanne). 2022 Nov 17;9:1065350. doi: 10.3389/fmed.2022.1065350. eCollection 2022.
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Arterial thrombosis and intracardiac thrombus as the initial presentation of a recurrent paraganglioma: case report and review of the literature.动脉血栓形成和心内血栓形成作为复发性副神经节瘤的首发表现:病例报告及文献复习。
Arch Endocrinol Metab. 2021 Nov 24;65(6):852-857. doi: 10.20945/2359-3997000000342. Epub 2021 Mar 19.
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A 40-YEAR FOLLOW-UP OF A PATIENT WITH MULTIPLE PARAGANGLIOMAS AND A SDHD MUTATION.一名患有多发性副神经节瘤且携带SDHD突变患者的40年随访
Acta Endocrinol (Buchar). 2019 Apr-Jun;15(2):254-260. doi: 10.4183/aeb.2019.254.
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Plasma concentrations of adrenomedullin and atrial and brain natriuretic peptides in patients with adrenal pheochromocytoma.肾上腺嗜铬细胞瘤患者血浆中肾上腺髓质素、心房利钠肽和脑利钠肽的浓度。
Oncol Lett. 2015 Nov;10(5):3163-3170. doi: 10.3892/ol.2015.3660. Epub 2015 Sep 2.
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[Resistant arterial hypertension and a prominent sternum in a 77-year-old woman].[一名77岁女性的顽固性动脉高血压与鸡胸]
Internist (Berl). 2014 Jul;55(7):847-50. doi: 10.1007/s00108-014-3495-9.