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结节性甲状腺肿患者降钙素测定及其对甲状腺髓样癌早期检测的意义:欧洲对美国甲状腺协会指南的评论

Calcitonin estimation in patients with nodular goiter and its significance for early detection of MTC: european comments to the guidelines of the American Thyroid Association.

作者信息

Elisei Rossella, Romei Cristina

机构信息

Department of Endocrinology and Metabolism, University of Pisa, Lungarno Pacinotti 43 - 56126 Pisa, Italy.

出版信息

Thyroid Res. 2013 Mar 14;6 Suppl 1(Suppl 1):S2. doi: 10.1186/1756-6614-6-S1-S2.

DOI:10.1186/1756-6614-6-S1-S2
PMID:23514432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3599715/
Abstract

One of the most discussed and controversial issue in the management of thyroid nodules is the need to perform a routine measurement of serum Calcitonin (Ct) in all cases. The American Thyroid Association guidelines do not recommend in favor or against this procedure since they retain that there are not enough evidences that it can determine an advantage to the health outcomes of these patients. This is not the view of many European experts who met in Lisbon in 2009 at the European Thyroid Association-Cancer Research Network meeting to discuss all the still open controversial issues on the management of medullary thyroid cancer patients.This paper is focused on the routine measurement of serum Ct in all patients with thyroid nodule(s): the evidences, the rational and the benefits of this procedure are deeply analysed following the discussion that was done in Lisbon. The conclusions reached at that time are reported in detail.

摘要

甲状腺结节管理中最受讨论且具争议性的问题之一,是是否需要对所有病例常规检测血清降钙素(Ct)。美国甲状腺协会指南未推荐支持或反对该检测,因为他们认为没有足够证据表明其能给这些患者的健康结局带来益处。但许多欧洲专家并不这么看,他们于2009年在里斯本召开的欧洲甲状腺协会 - 癌症研究网络会议上,讨论了甲状腺髓样癌患者管理中所有仍存争议的问题。本文聚焦于对所有甲状腺结节患者常规检测血清Ct:依据在里斯本的讨论,深入分析了该检测的证据、原理及益处。详细报告了当时得出的结论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c51c/3599715/f509edeecd3a/1756-6614-6-S1-S2-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c51c/3599715/f509edeecd3a/1756-6614-6-S1-S2-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c51c/3599715/f509edeecd3a/1756-6614-6-S1-S2-1.jpg

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J Clin Endocrinol Metab. 2012 Mar;97(3):905-13. doi: 10.1210/jc.2011-2033. Epub 2011 Dec 14.
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The timing of total thyroidectomy in RET gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years experience at one single center.基于降钙素水平,对 RET 基因突变携带者施行甲状腺全切除术的时机可以实现个体化,并安全规划:单中心 18 年经验。
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Update on Calcitonin Screening for Medullary Thyroid Carcinoma and the Results of a Retrospective Analysis of 12,984 Patients with Thyroid Nodules.
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Cancers (Basel). 2023 Apr 17;15(8):2333. doi: 10.3390/cancers15082333.
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Calcitonin: current concepts and differential diagnosis.降钙素:当前概念与鉴别诊断
Ther Adv Endocrinol Metab. 2022 May 21;13:20420188221099344. doi: 10.1177/20420188221099344. eCollection 2022.
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The dilemma of routine testing for calcitonin thyroid nodule's patients to detect or exclude medullary carcinoma: one single negative test should be valuable as rule-out strategy to avoid further calcitonin measurements over time.对于甲状腺结节患者进行降钙素常规检测以检测或排除甲状腺髓样癌的困境:单次阴性检测应该具有排除策略的价值,以避免随着时间的推移进行更多的降钙素检测。
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American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations.美国临床内分泌医师协会、意大利临床内分泌医师学会和欧洲甲状腺协会临床实践指南:甲状腺结节诊断和管理推荐的执行摘要。
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