狭叶辣木水提取物的体内外降压作用
In vivo and in vitro hypotensive effect of aqueous extract of Moringa stenopetala.
作者信息
Mengistu M, Abebe Y, Mekonnen Y, Tolessa T
机构信息
Department of Physiology, College of Health Sciences, Mekelle University, Ethiopia.
出版信息
Afr Health Sci. 2012 Dec;12(4):545-51.
BACKGROUND
Moringa stenopetala, Baker f. (Moringaceae) is used for food and medicine in Southern Ethiopia.
OBJECTIVE
To substantiate the hypotensive effect of M. stenopetala in vivo and in vitro.
METHODS
An in vivo experiment was carried out on male guinea pigs anaesthetized with pentobarbital. The arterial blood pressure was recorded from a carotid artery filled with heparinized saline via an arterial cannula connected to a pressure transducer. For the in vitro experiment the descending thoracic aorta was removed and kept moistened in Krebs-Henseleit solution and then mounted in a 20ml tissue bath maintained at 37°C and bubbled with a mixture of 95% oxygen and 5% carbon dioxide.
RESULTS
Crude aqueous leaf extract of M. stenopetala caused significant fall in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MABP) at doses of 10, 20, 30 and 40 mg/kg in normotensive anaesthetized guinea pigs (n = 12). The effect might have been mediated by non-autonomic nervous system as the effect is not altered by atropine and propranolol. The extract also caused significant dose and time dependent inhibition of K(+) induced contraction on guinea pig aorta.
CONCLUSION
M.stenopetala has blood pressure lowering effect substantiating the use of the plant in traditional medicine.
背景
狭瓣辣木（Moringa stenopetala, Baker f.，辣木科）在埃塞俄比亚南部被用于食品和医药。
目的
在体内和体外证实狭瓣辣木的降压作用。
方法
对用戊巴比妥麻醉的雄性豚鼠进行体内实验。通过连接压力传感器的动脉插管，从充满肝素化盐水的颈动脉记录动脉血压。体外实验中，取出胸降主动脉，置于克雷布斯-亨塞尔特溶液中保持湿润，然后安装在一个20ml、维持在37°C的组织浴中，并用95%氧气和5%二氧化碳的混合气体鼓泡。
结果
在血压正常的麻醉豚鼠（n = 12）中，狭瓣辣木的粗叶水提取物在剂量为10、20、30和40mg/kg时，可使收缩压（SBP）、舒张压（DBP）和平均动脉血压（MABP）显著下降。该作用可能由非自主神经系统介导，因为阿托品和普萘洛尔不会改变该作用。该提取物还对豚鼠主动脉上K(+)诱导的收缩产生显著的剂量和时间依赖性抑制。
结论
狭瓣辣木有降压作用，证实了该植物在传统医学中的应用。
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