Critchley H O, Chard T, Lieberman B A, Buckley C H, Anderson D C
University Department of Obstetrics and Gynaecology, Hope Hospital, Salford, London.
Hum Reprod. 1990 Apr;5(3):250-4. doi: 10.1093/oxfordjournals.humrep.a137082.
Data are presented on serum levels of the pregnancy-associated placental protein (PP14) in an XO mother, pregnant after frozen embryo transfer. Steroid replacement before and during early pregnancy was provided with transdermal oestradiol and vaginal micronized progesterone. Characterization of a pre-treatment cycle indicated a physiological response by the endometrium. The pregnancy was associated with normal maternal blood levels of all hormones considered responsible for maintenance of early gestation but with consistently subnormal serum levels of PP14. Hitherto, PP14 has been believed to be an endometrial protein arising from the decidua during pregnancy, under the influence of ovarian steroids. The findings in this case suggest that other factors are involved in its production, possibly under the control of, or originating from, the maternal ovary.
本文呈现了一位XO母亲在冷冻胚胎移植后怀孕时血清中妊娠相关胎盘蛋白（PP14）水平的数据。孕早期及孕期前给予经皮雌二醇和阴道微粒化孕酮进行类固醇替代治疗。预处理周期的特征表明子宫内膜有生理反应。此次妊娠与所有被认为对维持早期妊娠负责的母体血液激素水平正常相关，但PP14血清水平持续低于正常。迄今为止，PP14一直被认为是一种在孕期受卵巢类固醇影响，由蜕膜产生的子宫内膜蛋白。该病例的研究结果表明，其产生涉及其他因素，可能受母体卵巢控制或源于母体卵巢。
