Ul'ianov A M, Kudriashov B A
Vopr Med Khim. 1975 Jan-Feb;21(1):19-23.
Some physiological properties of a complex of factor XIII with heparin were studied in relatively pure system in vitro. The complex was shown to exhibite the fibrinolytic activity toward unstabilized fibrin in the presence or absence of xi-aminocapronic acid, optimal pH for the activity was at pH 6.5--7.5 The activity was still observed after heating at 60 degrees C for 30 min. An excess of heparin was found to block the specific hydrolytic activity of the complex studied. The possibility of transition of heparin from a complex adrenaline-heparin to factor XIII with formation of factor XIII--heparin complex was shown. As a result of interaction of heparin with factor XIII the latter lost the fibrin-stabilizing activity.
在相对纯净的体外系统中研究了因子 XIII 与肝素复合物的一些生理特性。该复合物在有或没有 ε-氨基己酸存在的情况下，对不稳定纤维蛋白表现出纤溶活性，活性的最适 pH 为 6.5 - 7.5。在 60℃加热 30 分钟后仍可观察到活性。发现过量的肝素会阻断所研究复合物的特异性水解活性。结果表明肝素可能从肾上腺素 - 肝素复合物转变为因子 XIII，并形成因子 XIII - 肝素复合物。由于肝素与因子 XIII 的相互作用，后者失去了纤维蛋白稳定活性。
