肿瘤转移：上皮-间质转化事件。
Tumor dissemination: an EMT affair.
机构信息
Department of Biochemistry, National University of Singapore, Singapore 117599.
出版信息
Cancer Cell. 2013 Mar 18;23(3):272-3. doi: 10.1016/j.ccr.2013.03.004.
PMID:23518345
Abstract
A recent paper reports that circulating tumor cells (CTCs) from metastatic breast cancer patients exhibit heterogeneous epithelial and mesenchymal phenotypes and that CTCs display higher frequencies of partial or full-blown mesenchymal phenotype than carcinoma cells within primary tumors. Mesenchymal-like CTCs are also elevated in patients who are refractory to therapy.
摘要
最近的一篇论文报道称，转移性乳腺癌患者的循环肿瘤细胞（CTCs）表现出异质性的上皮和间充质表型，并且 CTCs 显示出比原发性肿瘤中的癌细胞更高频率的部分或完全间充质表型。对治疗有抗药性的患者中也存在间充质样 CTCs。
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