Xue Juan-di, Xiang Wan-Fang, Cai Ming-Qin, Lv Xiao-Yun
The School of Basic Medicine Sciences of Lanzhou University, Lanzhou, China.
School/Hospital of Stomatology of Lanzhou University, Lanzhou, China.
Front Oncol. 2024 May 21;14:1332148. doi: 10.3389/fonc.2024.1332148. eCollection 2024.
Cancer is a heavy human burden worldwide, with high morbidity and mortality. Identification of novel cancer diagnostic and prognostic biomarkers is important for developing cancer treatment strategies and reducing mortality. Transcription factors, including SRY associated high mobility group box (SOX) proteins, are thought to be involved in the regulation of specific biological processes. There is growing evidence that SOX transcription factors play an important role in cancer progression, including tumorigenesis, changes in the tumor microenvironment, and metastasis. SOX5 is a member of SOX Group D of Sox family. SOX5 is expressed in various tissues of human body and participates in various physiological and pathological processes and various cellular processes. However, the abnormal expression of SOX5 is associated with cancer of various systems, and the abnormal expression of SOX5 acts as a tumor promoter to promote cancer cell viability, proliferation, invasion, migration and EMT through multiple mechanisms. In addition, the expression pattern of SOX5 is closely related to cancer type, stage and adverse clinical outcome. Therefore, SOX5 is considered as a potential biomarker for cancer diagnosis and prognosis. In this review, the expression of SOX5 in various human cancers, the mechanism of action and potential clinical significance of SOX5 in tumor, and the therapeutic significance of Sox5 targeting in cancer were reviewed. In order to provide a new theoretical basis for cancer clinical molecular diagnosis, molecular targeted therapy and scientific research.
癌症是全球沉重的人类负担，发病率和死亡率都很高。鉴定新型癌症诊断和预后生物标志物对于制定癌症治疗策略和降低死亡率至关重要。转录因子，包括SRY相关高迁移率族框（SOX）蛋白，被认为参与特定生物学过程的调控。越来越多的证据表明，SOX转录因子在癌症进展中发挥重要作用，包括肿瘤发生、肿瘤微环境变化和转移。SOX5是Sox家族D组的成员。SOX5在人体各种组织中表达，并参与各种生理和病理过程以及各种细胞过程。然而，SOX5的异常表达与各种系统的癌症相关，并且SOX5的异常表达通过多种机制作为肿瘤促进剂促进癌细胞的存活、增殖、侵袭、迁移和上皮-间质转化。此外，SOX5的表达模式与癌症类型、分期和不良临床结局密切相关。因此，SOX5被认为是癌症诊断和预后的潜在生物标志物。在本综述中，对SOX5在各种人类癌症中的表达、SOX5在肿瘤中的作用机制和潜在临床意义以及靶向Sox5在癌症中的治疗意义进行了综述。以便为癌症临床分子诊断、分子靶向治疗及科研提供新的理论依据。
