放线菌素A与羟基脲对细胞培养中DNA病毒复制的协同作用。
Synergic action of distamycin A and hydroxyurea on the reproduction of DNA viruses in cell cultures.
作者信息
Pancheva-Golvinska S
出版信息
Acta Virol. 1975 Jan;19(1):73-7.
PMID:235201
Abstract
The antiviral activity of the combination of distamycin A (DA) Pand hydroxyurea (HU) on the reproduction of vaccinia and pseudorabies viruses was investigated. The drug combination exerted a significant synergic inhibitory effect on the vaccinia virus yield and on the plaque formation in chick embryo cells. Similar experiments on pseudorabies virus showed an additive effect. The possible mechanism of the mutual enhancement of the antiviral activity is discussed.
摘要
研究了放线菌素A（DA）和羟基脲（HU）联合使用对痘苗病毒和伪狂犬病病毒复制的抗病毒活性。该药物组合对痘苗病毒产量以及鸡胚细胞中的蚀斑形成具有显著的协同抑制作用。对伪狂犬病病毒进行的类似实验显示出相加作用。文中讨论了抗病毒活性相互增强的可能机制。
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