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[骨修复中的生物材料]

[Biomaterials in bone repair].

作者信息

Puska Mervi, Aho Allan J, Vallittu Pekka K

机构信息

Turun yliopisto, TCBC.

出版信息

Duodecim. 2013;129(5):489-96.

Abstract

In orthopedics, traumatology, and craniofacial surgery, biomaterials should meet the clinical demands of bone that include shape, size and anatomical location of the defect, as well as the physiological load-bearing stresses. Biomaterials are metals, ceramics, plastics or materials of biological origin. In the treatment of large defects, metallic endoprostheses or bone grafts are employed, whereas ceramics in the case of small defects. Plastics are employed on the artificial joint surfaces, in the treatment of vertebral compression fractures, and as biodegradable screws and plates. Porosity, bioactivity, and identical biomechanics to bone are fundamental for achieving a durable, well-bonded, interface between biomaterial and bone. In the case of severe bone treatments, biomaterials should also imply an option to add biologically active substances.

摘要

在骨科、创伤外科和颅面外科中,生物材料应满足骨骼的临床需求,包括缺损的形状、大小和解剖位置,以及生理承重应力。生物材料包括金属、陶瓷、塑料或生物源材料。在治疗大的缺损时,采用金属内固定假体或骨移植,而小缺损则使用陶瓷。塑料用于人工关节表面、治疗椎体压缩骨折以及作为可生物降解的螺钉和钢板。孔隙率、生物活性以及与骨骼相同的生物力学性能是在生物材料与骨骼之间实现持久、良好结合界面的基础。在严重的骨治疗中,生物材料还应具备添加生物活性物质的选项。

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