氯胺酮：在麻醉中的应用。
Ketamine: use in anesthesia.
机构信息
Care Flight, Sydney, NSW, Australia.
出版信息
CNS Neurosci Ther. 2013 Jun;19(6):381-9. doi: 10.1111/cns.12072. Epub 2013 Mar 22.
Abstract
The role of ketamine anesthesia in the prehospital, emergency department and operating theater settings is not well defined. A nonsystematic review of ketamine was performed by authors from Australia, Europe, and North America. Results were discussed among authors and the final manuscript accepted. Ketamine is a useful agent for induction of anesthesia, procedural sedation, and analgesia. Its properties are appealing in many awkward clinical scenarios. Practitioners need to be cognizant of its side effects and limitations.
摘要
氯胺酮在院前、急诊科和手术室的作用尚未明确。来自澳大利亚、欧洲和北美的作者对氯胺酮进行了非系统性回顾。作者之间讨论了结果，最终接受了手稿。氯胺酮是一种用于诱导麻醉、程序镇静和镇痛的有效药物。其特性在许多棘手的临床情况下很有吸引力。从业者需要意识到其副作用和局限性。
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3
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