创伤与重症监护强化康复指南(ERATIC):外科手术强化康复(ERAS)与国际创伤外科与重症监护协会(IATSIC)学会推荐意见:论文2:术后及重症监护推荐意见

Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC): Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Paper 2: Postoperative and Intensive Care Recommendations.

作者信息

Hardcastle Timothy C, Gaarder Christine, Balogh Zsolt, D'amours Scott, Davis Kimberly A, Gupta Amit, Mohseni Shahin, Naess Paal A, Naidoo Shanisa, Razek Tarek, Robertson Simon, Uchino Hayaki, Zonies David, Whing Jade, Scott Michael J

机构信息

Inkosi Albert Luthuli Central Hospital, Durban, South Africa.

Department of Surgical Sciences, University of KwaZulu-Natal, Durban, South Africa.

出版信息

World J Surg. 2025 Aug;49(8):2029-2054. doi: 10.1002/wjs.70004. Epub 2025 Jul 22.

Abstract

BACKGROUND

Enhanced recovery after surgery (ERAS) protocols reduce length of stay, complications, and costs for elective surgical procedures. It remains challenging to implement ERAS concepts in the acute trauma patient due to deranged physiological reserve from the penetrating or blunt trauma producing altered physiology. However, systems of care improve access to early intervention and potentially reduce mortality. These consensus guidelines examine optimal prehospital, resuscitation-room, intraoperative and postoperative treatment, systems of ethical management, and overall care for trauma patients in the postresuscitation phase of care. The guideline is presented in three parts, this being Part 2.

METHODS

Experts in aspects of management of trauma surgical patients and intensive care were invited to contribute by the International ERAS Society and IATSIC. PubMed, Cochrane, Embase, and MEDLINE database searches on English language publications were performed for ERAS elements using the patient, intervention, comparator outcome (PICO) consensus questions created by the expert group. Studies were selected with particular attention to randomized clinical trials, systematic reviews, meta-analyses, and large cohort studies; reviewed and summarized recommendations were graded using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. These recommendations based on current best evidence, with extrapolation from elective patient studies, where appropriate, were followed by a modified two-round Delphi method to validate final recommendations. Several ERAS components are already standard of care within national and society guidelines and are endorsed. The bulk of the text focuses on key areas pertaining specifically to trauma care of major trauma and polytrauma in the ICU-requiring group.

RESULTS

Overall, 37 aspects of trauma care were considered, with multiple PICO questions and subpoints. Consensus was reached after two rounds of a modified Delphi process involving all authors, with minor adjustments to some phrasing required, but with 87% overall agreement on all statements (100% agreement on 31 of the main statement sets, prior to minor edits to address the points of difference for the rest, with 100% total agreement thereafter). None were rejected outright. The recommendations and level of evidence for each aspect of trauma care that may impact on improved recovery and reduced length of hospital stay are presented with grade of recommendation.

CONCLUSIONS

This paper presents the results of the postoperative care and ICU aspects. The guidelines are based on current best evidence for an ERAS approach to patients who have had major injuries and polytrauma. These guidelines are not exhaustive but collate the best available evidence on important components of care for this patient population. As some of the evidence is extrapolated from elective surgery and nontrauma emergency surgery, some of the components need further evaluation in future studies.

摘要

背景

术后加速康复(ERAS)方案可缩短择期手术患者的住院时间、减少并发症并降低费用。由于穿透性或钝性创伤导致生理储备紊乱,生理机能改变,在急性创伤患者中实施ERAS理念仍具有挑战性。然而,医疗系统可改善早期干预的可及性并可能降低死亡率。这些共识指南探讨了创伤患者复苏后阶段的最佳院前、复苏室、术中及术后治疗、伦理管理系统及整体护理。本指南分为三个部分,本文为第二部分。

方法

国际ERAS学会和国际创伤与重症医学协会邀请了创伤外科患者管理和重症监护方面的专家参与。使用专家组提出的患者、干预措施、对照结局(PICO)共识问题,在PubMed、Cochrane、Embase和MEDLINE数据库中检索关于ERAS要素的英文出版物。研究选择特别关注随机临床试验、系统评价、荟萃分析和大型队列研究;使用推荐分级、评估、制定与评价(GRADE)系统对审查和总结的建议进行分级。这些基于当前最佳证据并在适当情况下从择期患者研究推断得出的建议,随后采用改良的两轮德尔菲法来验证最终建议。一些ERAS组成部分已经是国家和社会指南中的标准治疗方法并得到认可。本文大部分内容聚焦于专门针对需要入住重症监护病房的严重创伤和多发伤患者创伤护理的关键领域。

结果

总体而言,共考虑了37个创伤护理方面,有多个PICO问题及子要点。在所有作者参与的两轮改良德尔菲过程后达成了共识,只需对某些措辞进行微小调整,但对所有陈述的总体同意率为87%(在对其余部分的分歧点进行微小编辑之前,对31个主要陈述集的同意率为100%,之后总体同意率为100%)。没有一项被直接否决。列出了可能影响改善康复和缩短住院时间的创伤护理各方面的建议及证据水平,并给出了推荐等级。

结论

本文介绍了术后护理和重症监护方面的结果。这些指南基于当前关于对严重受伤和多发伤患者采用ERAS方法的最佳证据。这些指南并不详尽,但整理了关于该患者群体重要护理组成部分的现有最佳证据。由于一些证据是从择期手术和非创伤性急诊手术推断而来,一些组成部分需要在未来研究中进一步评估。

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