Nishimura Y, Inaba J, Watari K, Matsusaka N
Division of Environmental Health, National Institute of Radiological Sciences, Chiba-shi, Japan.
J Radiat Res. 1990 Mar;31(1):110-8. doi: 10.1269/jrr.31.110.
106RuNO-nitro complex was administered intravenously to pregnant rats to study uptake of the radioruthenium complex by the conceptus in relation to gestational stages. Each conceptus was sampled periodically with respect to its placenta, fetal membrane, fetal fluid and fetus. Perceptible radioactivity in the fetus was detected only in the later stage of gestation and its relative concentration, defined as the ratio radioactivity per unit weight in the body tissue at sacrifice to that in the whole-body at dosing, was very low compared with other tissues. The average number of fetuses in one litter was 13 and the transfer rate of nitro complex into the fetuses 24 hr after injection to rats on the 20th day of gestation was about 1% of initial maternal dose. The relative concentration in the placenta and fetal membrane was much higher than in the fetus and decreased with time after injection. These results indicate that the placenta and fetal membrane play significant roles as barriers to the transfer of 106RuNO-nitro complex into the fetus.
将106RuNO - 硝基配合物静脉注射给怀孕大鼠，以研究放射性钌配合物在不同妊娠阶段被孕体摄取的情况。对每个孕体的胎盘、胎膜、羊水和胎儿进行定期取样。仅在妊娠后期检测到胎儿体内有明显的放射性，其相对浓度（定义为处死时身体组织单位重量的放射性与给药时全身放射性之比）与其他组织相比非常低。一窝胎儿的平均数量为13个，在妊娠第20天给大鼠注射后24小时，硝基配合物向胎儿的转移率约为母体初始剂量的1%。胎盘和胎膜中的相对浓度远高于胎儿，并在注射后随时间下降。这些结果表明，胎盘和胎膜在阻碍106RuNO - 硝基配合物向胎儿转移方面起着重要作用。
