Nishimura Y, Sahoo S K, Kim H S, Homma-Takeda S, Watanabe Y, Inaba J
National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba-shi, 263-8555, Japan.
Radiat Prot Dosimetry. 2003;105(1-4):285-90. doi: 10.1093/oxfordjournals.rpd.a006241.
Radiotellurium is present in the environment primarily due to its release during nuclear reactor accidents. Little is known of tellurium metabolism in juveniles, although the element is relatively abundant and has a number of industrial uses. A biokinetic study of radiotellurium in rats was performed using gamma-ray counting. Wistar strain rats were used to determine the uptake of H2(123m)TeO3 by the whole-body retention of juvenile rats and the conceptus in relation to its gestational stages, by measurements in the placenta, fetal membranes, fetal fluid and fetus. The whole-body retention of 123mTe in juvenile rats was higher than that of adult rats. The relative concentration in the placenta and fetal membranes was higher than in the fetus. No activity was observed in the fetal fluid. These results indicate that the placenta and fetal membranes play significant roles as barriers to the transfer of 123mTe into the fetus. The ratio, relative concentration in fetus/relative concentration in mother (C(F)/C(M)), was calculated. The C(F)/C(M) ratio was dependent on the stage of gestation and ranged from 0.2 to 0.5. A little 123mTe was transferred to the suckling rats through the mother's milk when the isotope was administered intravenously to the mother.
放射性碲在环境中的存在主要是由于其在核反应堆事故期间的释放。尽管碲元素相对丰富且有许多工业用途，但人们对其在幼体中的代谢了解甚少。使用伽马射线计数法对大鼠体内的放射性碲进行了生物动力学研究。通过对胎盘、胎膜、羊水和胎儿的测量，利用Wistar品系大鼠来确定幼体大鼠和不同妊娠阶段的胎儿对H2(123m)TeO3的摄取情况以及全身滞留情况。幼体大鼠体内123mTe的全身滞留量高于成年大鼠。胎盘和胎膜中的相对浓度高于胎儿。羊水中未观察到放射性活度。这些结果表明，胎盘和胎膜在阻止123mTe向胎儿转移方面发挥着重要作用。计算了胎儿/母体相对浓度比（C(F)/C(M)）。C(F)/C(M)比值取决于妊娠阶段，范围为0.2至0.5。当给母体静脉注射该同位素时，少量123mTe会通过母乳转移到乳鼠体内。
