FIDMAG Germanes Hospitalàries, Barcelona, Spain.
Schizophr Res. 2013 May;146(1-3):308-13. doi: 10.1016/j.schres.2013.02.032. Epub 2013 Mar 20.
Formal thought disorder (FTD) in schizophrenia has been found to be associated with volume reductions in the left superior temporal cortex. However, there have been negative findings and some studies have also found associations in other cortical regions.
Fifty-one schizophrenic patients were evaluated for presence of FTD with the Thought, Language and Communication (TLC) scale and underwent whole-brain structural MRI using optimized voxel-based morphometry (VBM). Fifty-nine matched healthy controls were also scanned.
Compared to 31 patients without FTD (global TLC rating 0 or 1), 20 patients with FTD (global TLC rating 2-5) showed clusters of volume reduction in the medial frontal and orbitofrontal cortex bilaterally, and in two left-sided areas approximating to Broca's and Wernicke's areas. The pattern of FTD-associated volume reductions was largely different from that found in a comparison between the healthy controls and the patients without FTD. Analysis of correlations within regions-of-interest based on the above clusters indicated that the 'fluent disorganization' component of FTD was correlated with volume reductions in both Broca's and Wernicke's areas, whereas poverty of content of speech was correlated with reductions in the medial frontal/orbitofrontal cortex.
The findings point to a relationship between FTD in schizophrenia and structural brain pathology in brain areas involved in language and executive function.
精神分裂症患者的思维形式障碍（FTD）与左侧颞上皮质体积减少有关。然而，也有一些阴性发现，一些研究还发现了其他皮质区域的关联。
51 名精神分裂症患者接受了思维、语言和交流（TLC）量表的 FTD 评估，并使用优化的基于体素的形态测量学（VBM）进行了全脑结构 MRI 扫描。还对 59 名匹配的健康对照组进行了扫描。
与 31 名无 FTD（TLC 总评分 0 或 1）的患者相比，20 名有 FTD（TLC 总评分 2-5）的患者双侧额内侧和眶额皮质以及两个左侧区域（近似于布罗卡区和韦尼克区）出现了体积减少的集群。FTD 相关体积减少的模式与健康对照组和无 FTD 患者之间的比较有很大的不同。基于上述集群的感兴趣区域分析表明，FTD 的“流畅性紊乱”成分与布罗卡区和韦尼克区的体积减少相关，而言语内容匮乏与额内侧/眶额皮质的减少相关。
这些发现表明精神分裂症患者的 FTD 与语言和执行功能相关脑区的结构脑病理学之间存在关系。
