Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
Schizophr Res. 2013 Aug;148(1-3):168-74. doi: 10.1016/j.schres.2013.05.021. Epub 2013 Jun 12.
Neuroanatomical abnormalities are considered to be related to the pathogenesis of schizophrenia. Reversal or reduction of normal structural cerebral asymmetries in schizophrenia is particularly striking. The current study investigated the alteration of gray matter volume and cerebral asymmetry in early stage of first-episode schizophrenia (FESZ), and their correlations with clinical measures. Magnetic resonance imaging scans were obtained from a total of 89 participants. Thirty-three FESZ patients and 41 matched healthy controls were included in the analysis. Compared to healthy controls, the FESZ patients showed decreased gray matter volume (GMV) in the frontal cortex, anterior cingulate cortex, temporal cortex, parahippocampal, fusiform, insula, and lingual; and increased GMV in cerebellum. Both male and female patients displayed an increased rightward lateralization in frontal and temporal cortex, which was significantly correlated with the severity of symptoms and social functioning. These findings may provide the neurological substrate for the etiology and clinical manifestations of the illness.
神经解剖异常被认为与精神分裂症的发病机制有关。精神分裂症中正常结构的大脑不对称性的逆转或减少尤为明显。本研究探讨了首发精神分裂症（FESZ）早期灰质体积和大脑不对称性的变化，以及它们与临床指标的相关性。对总共 89 名参与者进行了磁共振成像扫描。分析中包括 33 名 FESZ 患者和 41 名匹配的健康对照组。与健康对照组相比，FESZ 患者的额皮质、前扣带皮质、颞皮质、海马旁回、梭状回、岛叶和舌回的灰质体积（GMV）减少，小脑 GMV 增加。男性和女性患者的额皮质和颞皮质的右侧化程度增加，这与症状的严重程度和社会功能显著相关。这些发现可能为疾病的病因和临床表现提供神经基础。
