Department of Histopathology, Centre Jean Perrin, Clermont-Ferrand, France; Department of Surgery, Centre Jean Perrin, Clermont-Ferrand, France; Department of Obstetrics and Gynecology, CHU St Etienne, France.
Crit Rev Oncol Hematol. 2013 Oct;88(1):134-43. doi: 10.1016/j.critrevonc.2013.03.004. Epub 2013 Mar 22.
Our understanding of the early natural history of epithelial ovarian carcinoma is limited by the access to early lesions as the disease is very often diagnosed at advanced stages. The incessant ovulation theory from the last century that indicated the ovary as the site for the initiation of high-grade serous cancers is contrary to the newly emerging idea that ovarian cancer could arise from the distal fallopian tube. In view of the recent pathological and molecular studies, we propose to discuss the genesis of high-grade serous ovarian cancer.
我们对上皮性卵巢癌早期自然史的认识受到早期病变获取途径的限制，因为这种疾病通常在晚期才被诊断出来。上个世纪提出的“持续排卵理论”表明卵巢是高级别浆液性癌的起源部位，而这一理论与新出现的观点相矛盾，即卵巢癌可能起源于输卵管远端。鉴于最近的病理学和分子研究，我们拟对高级别浆液性卵巢癌的发生机制进行讨论。
