Eken Meryem, Temizkan Osman, Kaygusuz Ecmel Işık, Herkiloğlu Dilşad, Çöğendez Ebru, Karateke Ateş
Zeynep Kamil Training and Research Hospital, Clinic of Gynecology and Obstetrics, İstanbul, Turkey.
Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Gynecology and Obstetrics, İstanbul, Turkey.
Turk J Obstet Gynecol. 2015 Jun;12(2):83-88. doi: 10.4274/tjod.67355. Epub 2015 Jun 15.
The aim of this study was to review patients with tubal carcinoma who underwent surgery in our clinic due to primary carcinoma of the fallopian tubes, a very rare gynecologic malignancy.
Sixteen patients who were diagnosed as having primary carcinoma of the fallopian tubes and underwent surgery in Zeynep Kamil Research and Training Hospital between January 2007 and December 2014 were included in the study. Demographic data such as age, gravidity, parity, menopausal condition, symptoms, adjuvant therapy, recurrence of tumor, as well as time and type of operation were extracted from patient epicrisis reports and oncology files. Patient information was extracted from the patients' current files and phone calls were made with patients and their relatives.
The mean age of patients was 59.6 (range, 43-78) years. Seventy-five percent of the women were menopausal at admission; the mean menopause duration was 10 years (range, 1-20 years). None of the patients were nulliparous and mean parity was 4.3 (2-8). The most common presenting symptom was abdominopelvic pain, followed by abnormal uterine bleeding. The most common histopathologic type was high-grade serous carcinoma. The mean follow-up duration was 23.7 months (range, 2-53 months). During follow-up, recurrence was seen in 4 (25%) patients. One patient left the study during follow-up. The mean disease-free survival was 48 months. No relation was found between disease-free survival, age, stage, grade, and histologic type in univariate logistic regression analysis.
Primary carcinoma of the fallopian tubes is a rare gynecologic tumor that is seen in older patients, has no specific signs, and usually cannot be diagnosed before surgery. Therefore, we think that large-series, multi-centered studies with long-term follow-up duration are needed to define its etiopathogenesis and treatment strategies for the disease.
本研究旨在回顾因原发性输卵管癌（一种非常罕见的妇科恶性肿瘤）在我院接受手术治疗的输卵管癌患者。
纳入2007年1月至2014年12月期间在泽伊内普·卡米尔研究与培训医院被诊断为原发性输卵管癌并接受手术的16例患者。从患者病历报告和肿瘤学档案中提取年龄、妊娠次数、产次、绝经状态、症状、辅助治疗、肿瘤复发以及手术时间和类型等人口统计学数据。从患者当前档案中提取患者信息，并与患者及其亲属进行电话沟通。
患者的平均年龄为59.6岁（范围43 - 78岁）。75%的女性入院时已绝经；平均绝经时间为10年（范围1 - 20年）。所有患者均非未育，平均产次为4.3（2 - 8）。最常见的首发症状是腹盆腔疼痛，其次是子宫异常出血。最常见的组织病理学类型是高级别浆液性癌。平均随访时间为23.7个月（范围2 - 53个月）。随访期间，4例（25%）患者出现复发。1例患者在随访期间退出研究。平均无病生存期为48个月。单因素逻辑回归分析未发现无病生存期与年龄、分期、分级和组织学类型之间存在关联。
原发性输卵管癌是一种罕见的妇科肿瘤，多见于老年患者，无特异性体征，术前通常无法诊断。因此，我们认为需要进行大样本、多中心且长期随访的研究来明确其发病机制和疾病的治疗策略。
