The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
FEBS Lett. 2013 May 2;587(9):1399-404. doi: 10.1016/j.febslet.2013.03.017. Epub 2013 Mar 21.
Trypanosome protozoan parasites are the causative agents of devastating diseases. Trypanosome telomeres grow in an uncontrolled manner and the variant surface glycoprotein (VSG) genes are located in subtelomeric domains. The gene encoding telomerase reverse transcriptase (TERT) was identified and in this study, we describe the Trypanosoma brucei telomerase RNA (TER). TER RNA is bound by the core proteins of the C/D small nucleolar RNA (snoRNA) family and associates with the methyltransferase-associated protein (MTAP), whose homologue binds to mammalian TER. Silencing of TbTER resulted in telomere shortening. This is the first report of a TER that binds the C/D snoRNA core proteins.
锥虫原生动物寄生虫是毁灭性疾病的病原体。锥虫端粒以不受控制的方式生长，变异表面糖蛋白（VSG）基因位于端粒域。端粒酶逆转录酶（TERT）的编码基因已被鉴定，在本研究中，我们描述了布鲁氏锥虫端粒酶 RNA（TER）。TER RNA 与 C/D 小核仁 RNA（snoRNA）家族的核心蛋白结合，并与甲基转移酶相关蛋白（MTAP）相关联，其同源物与哺乳动物 TER 结合。TbTER 的沉默导致端粒缩短。这是第一个报道与 C/D snoRNA 核心蛋白结合的 TER。
