Engerman R L, Kern T S, Larson M E
Department of Ophthalmology, University of Wisconsin School of Medicine, Madison.
Metabolism. 1990 Jun;39(6):638-40. doi: 10.1016/0026-0495(90)90032-8.
To evaluate the role of hyperglycemia and excessive polyol pathway activity in the pathogenesis of nerve disorders in diabetes, motor nerve conduction velocity (MNCV) was measured in dogs alloxan diabetic or experimentally galactosemic for 5 years. Diabetic dogs in poor glycemic control showed a progressive decline of MNCV from baseline values. Diabetic dogs that had been randomly assigned to good glycemic control retained normal MNCV. Nondiabetic dogs made galactosemic by a 30% galactose diet developed erythrocyte polyol concentrations many-fold greater than in diabetic animals, but the MNCV remained unchanged and comparable to that of normal dogs. Nerve polyol levels, when compared in short-term diabetic dogs or dogs galactose-fed 2 to 4 months, were elevated at least as much by the galactose-rich diet as by diabetes. Thus, in dogs, excessive tissue polyol accumulation is associated with subnormal MNCV in diabetes, but not in experimental galactosemia.
为评估高血糖和多元醇途径过度激活在糖尿病神经病变发病机制中的作用，我们对用四氧嘧啶诱导糖尿病或实验性半乳糖血症5年的犬只进行了运动神经传导速度（MNCV）测定。血糖控制不佳的糖尿病犬，其MNCV较基线值呈进行性下降。随机分配至血糖良好控制组的糖尿病犬，其MNCV保持正常。通过30%半乳糖饮食诱导半乳糖血症的非糖尿病犬，其红细胞多元醇浓度比糖尿病动物高出许多倍，但MNCV保持不变，与正常犬相当。短期糖尿病犬或半乳糖喂养2至4个月的犬只相比，富含半乳糖的饮食和糖尿病至少同等程度地升高了神经多元醇水平。因此，在犬类中，组织多元醇过度蓄积在糖尿病中与MNCV低于正常有关，但在实验性半乳糖血症中并非如此。
