棘层松解性鳞状细胞癌中细胞间黏附分子的表达降低，与皮肤浸润性高分化鳞状细胞癌相比。

Decreased expression of intercellular adhesion molecules in acantholytic squamous cell carcinoma compared with invasive well-differentiated squamous cell carcinoma of the skin.

机构信息

Dept of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

出版信息

Am J Clin Pathol. 2013 Apr;139(4):442-7. doi: 10.1309/AJCPTN4BNJYIRUWO.

Abstract

Intercellular adhesion proteins are poorly characterized in acantholytic squamous cell carcinoma (ASCC), a more aggressive tumor than nonacantholytic invasive well-differentiated squamous cell carcinoma (SCC) of the skin. In this study we compared expression of Dsg3, E-cadherin, and syndecan-1 in ASCC and SCC. Immunohistochemical detection of Dsg3, E-cadherin, and syndecan-1 in 22 ASCCs and 22 SCCs was graded on a semiquantitative scale for intensity of staining (SI) and degree of circumferential staining (CS) about the cell membrane. Results were assessed by means of conditional logistic regression and χ(2) analysis. Dsg3 and E-cadherin expression (SI, CS) was significantly decreased (P < .05) in ASCC compared with SCC, whereas staining for syndecan-1 was similar in the 2 tumor types. Differences in expression of adhesion markers between ASCC and SCC may contribute to the development of acantholysis in ASCC and its more aggressive biologic behavior.

摘要

细胞间黏附蛋白在棘层松解性鳞状细胞癌（ASCC）中特征不明显，这种肿瘤比非棘层松解性浸润性高分化鳞状细胞癌（SCC）更具侵袭性。在这项研究中，我们比较了 Dsg3、E-钙黏蛋白和 syndecan-1 在 ASCC 和 SCC 中的表达。用免疫组织化学方法检测 22 例 ASCC 和 22 例 SCC 中 Dsg3、E-钙黏蛋白和 syndecan-1 的表达，用染色强度（SI）和细胞膜周围染色程度（CS）的半定量评分来分级。用条件逻辑回归和 χ(2)分析来评估结果。与 SCC 相比，ASCC 中 Dsg3 和 E-钙黏蛋白的表达（SI、CS）显著降低（P <.05），而 syndecan-1 的染色在 2 种肿瘤类型中相似。ASCC 和 SCC 之间黏附标志物表达的差异可能有助于 ASCC 中棘层松解的发展及其更具侵袭性的生物学行为。