棘层松解性鳞状细胞癌中的桥粒缺陷
Desmosomal defects in acantholytic squamous cell carcinomas.
作者信息
O'Shea Charlene, Fitzpatrick James E, Koch Peter J
机构信息
Department of Dermatology, University of Colorado School of Medicine, Aurora, CO, USA; Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado School of Medicine, Aurora, CO, USA.
出版信息
J Cutan Pathol. 2014 Nov;41(11):873-9. doi: 10.1111/cup.12390. Epub 2014 Nov 4.
BACKGROUND
Acantholytic squamous cell carcinoma (Acantholytic SCC) are epithelial tumors characterized by a loss of cell adhesion between neoplastic keratinocytes. The mechanism underlying loss of cell-cell adhesion in these tumors is not understood.
METHODS
A retrospective analysis of acantholytic SCC (n = 17) and conventional SCC (n = 16, controls not showing acantholysis) was conducted using a set of desmosomal and adherens junction protein antibodies. Immunofluorescence microscopy was used to identify tumors with loss of adhesion protein expression.
RESULTS
The vast majority of acantholytic SCC (89%) showed focal loss of at least one desmosomal cell adhesion protein. Most interestingly, 65% of these tumors lost expression of two or more desmosomal proteins.
CONCLUSIONS
Loss of cell adhesion in acantholytic SCC is most likely linked to the focal loss of desmosomal protein expression, thus providing potential mechanistic insight into the patho-mechanism underlying this malignancy.
背景
棘层松解性鳞状细胞癌（Acantholytic SCC）是一种上皮性肿瘤，其特征为肿瘤性角质形成细胞之间细胞黏附丧失。这些肿瘤中细胞间黏附丧失的潜在机制尚不清楚。
方法
使用一组桥粒和黏着连接蛋白抗体对棘层松解性鳞状细胞癌（n = 17）和传统鳞状细胞癌（n = 16，作为不显示棘层松解的对照）进行回顾性分析。采用免疫荧光显微镜鉴定黏附蛋白表达缺失的肿瘤。
结果
绝大多数棘层松解性鳞状细胞癌（89%）显示至少一种桥粒细胞黏附蛋白的局灶性缺失。最有趣的是，这些肿瘤中有65%丧失了两种或更多种桥粒蛋白的表达。
结论
棘层松解性鳞状细胞癌中的细胞黏附丧失很可能与桥粒蛋白表达的局灶性缺失有关，从而为这种恶性肿瘤的发病机制提供了潜在的机制性见解。
Zotero 插件