Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
Jpn J Radiol. 2013 Jun;31(6):424-7. doi: 10.1007/s11604-013-0201-0. Epub 2013 Mar 24.
To evaluate differences in the viscosity of a platinum iodized-oil suspension on the kind of platinum agent and temperature.
Viscosities of a 70 mg miriplatin and 3.5 ml iodized-oil suspension (MO suspension) and that of 100 mg cisplatin and 10 ml iodized-oil suspension (CO suspension) were evaluated at three temperatures: 25, 37, and 50 °C. Iodized-oil was used as the control. Each liquid was injected into a capillary tube and allowed to drip separately. The liquid transit time was measured, and the viscosity of each liquid was calculated at each temperature.
The viscosity of each liquid decreased as the temperature increased: 43.3 ± 0.5, 39.2 ± 0.7, and 34.7 ± 0.6 mPa s for MO suspension, 41.3 ± 0.2, 36.9 ± 0.3, and 32.7 ± 0.9 mPa s for CO suspension, and 40.5 ± 0.2, 36.8 ± 0.2, and 33.8 ± 0.7 mPa s for iodized-oil at 25, 37, and 50 °C, respectively. The MO suspension group viscosity was significantly higher than that of the CO suspension group (p < 0.05) and the control (p < 0.05). Significant differences were found in viscosities among groups divided by temperature (25 °C-group vs. 37 °C-group, p < 0.05; 37 °C-group vs. 50 °C-group, p < 0.05).
The viscosity of the platinum iodized-oil suspension can be adjusted by changing temperature.
评估不同铂制剂和温度对碘化油混悬液粘度的影响。
评估 70mg/miriplatin 和 3.5ml 碘化油混悬液（MO 混悬液）以及 100mg 顺铂和 10ml 碘化油混悬液（CO 混悬液）在三种温度（25、37 和 50°C）下的粘度。以碘化油作为对照。将每种液体注入毛细管并单独滴注。测量液体通过时间，并计算每种液体在每个温度下的粘度。
每种液体的粘度随温度升高而降低：MO 混悬液分别为 43.3±0.5、39.2±0.7 和 34.7±0.6 mPa·s，CO 混悬液分别为 41.3±0.2、36.9±0.3 和 32.7±0.9 mPa·s，碘化油分别为 40.5±0.2、36.8±0.2 和 33.8±0.7 mPa·s，在 25、37 和 50°C 下。MO 混悬液组的粘度明显高于 CO 混悬液组（p<0.05）和对照组（p<0.05）。按温度分组的粘度存在显著差异（25°C 组与 37°C 组，p<0.05；37°C 组与 50°C 组，p<0.05）。
通过改变温度可以调节铂碘化油混悬液的粘度。
