de Baere T, Zhang X, Aubert B, Harry G, Lagrange C, Ropers J, Dufaux J, Lumbroso J, Rougier P, Ducreux M, Roche A
Department of Interventional Radiology, Institut Gustave Roussy, Villejuif, France.
Radiology. 1996 Dec;201(3):731-5. doi: 10.1148/radiology.201.3.8939223.
To optimize use of iodized oil for diagnostic computed tomography (CT) enhanced with iodized oil and for interstitial radiation therapy with iodine-131-labeled iodized oil, the authors quantified the distribution of iodized oil after injection of different formulations of iodized oil into the hepatic artery.
I-125-labeled iodinated ethyl ester of poppyseed oil in two viscosities (iodized oil ultrafluid [viscosity, 0.04 Pa/sec] and iodized oil fluid [viscosity, 0.17 Pa/sec]) was injected (pure forms and three different emulsions of each) into the hepatic artery of rabbits bearing VX2 tumors in the liver. All rabbits received a radiation dose of 4 MBq per kilogram of body weight in 0.1 mL/kg iodized oil. Animals were killed 4 days later, and iodized oil uptake was evaluated in the tumor, nontumorous liver, and lung.
There were no statistically significant differences in uptake between pure iodized oil ultrafluid or fluid or between the same type of emulsions made with each type of iodized oil. Lung uptake was significantly higher with pure iodized oil ultrafluid and fluid (19.75 kBq/g +/- 3.25 [standard error of the mean] vs 19.48 kBq/g +/- 6.15, respectively) than with any emulsions (range, 3.72-8.14 kBq/g; mean, 5.68 kBq/g) except the small-droplet oil-in-water emulsion (10.51 kBq/g +/- 1.18). The ratio of tumor to nontumorous liver uptake of iodized oil was significantly higher with large-droplet water-in-oil emulsions made of iodized oil ultrafluid or fluid (10.26 +/- 2.88 and 9.53 +/- 0.64, respectively) than with any other product (range, 4.07-5.38; mean, 4.49).
Use of large-droplet water-in-oil emulsions limited lung uptake and increased tumor uptake of iodized oil after intraarterial hepatic injection in rabbits bearing VX2 tumors in the liver.
为优化碘化油在碘化油增强诊断性计算机断层扫描（CT）及碘-131标记碘化油间质放射治疗中的应用，作者对不同剂型的碘化油注入肝动脉后碘化油的分布进行了量化研究。
将两种不同黏度（超流体碘化油[黏度，0.04Pa/秒]和流体碘化油[黏度，0.17Pa/秒]）的I-125标记罂粟籽油碘乙酯（每种的纯品及三种不同乳剂）注入肝脏有VX2肿瘤的兔肝动脉。所有兔接受每千克体重4MBq的放射剂量，溶于0.1mL/kg碘化油中。4天后处死动物，评估肿瘤、非肿瘤肝脏及肺中碘化油的摄取情况。
纯超流体碘化油或流体碘化油之间，或每种碘化油制成的同类型乳剂之间，摄取情况无统计学显著差异。纯超流体碘化油和流体碘化油的肺摄取量（分别为19.75kBq/g±3.25[平均标准误]和19.48kBq/g±6.15）显著高于除小滴水包油乳剂（10.51kBq/g±1.18）外的任何乳剂（范围，3.72 - 8.14kBq/g；平均，5.68kBq/g）。由超流体碘化油或流体碘化油制成的大滴油包水乳剂的碘化油肿瘤与非肿瘤肝脏摄取比（分别为10.26±2.88和9.53±0.64）显著高于任何其他产品（范围，4.07 - 5.38；平均，4.49）。
对于肝脏有VX2肿瘤的兔，肝动脉内注射后，使用大滴油包水乳剂可限制肺摄取并增加碘化油的肿瘤摄取。
