Duke Clinical Research Institute, Duke University Medical Center, Box 3126, Durham, NC, 27710, USA.
Curr Cardiol Rep. 2013 May;15(5):356. doi: 10.1007/s11886-013-0356-4.
Hypertension is thought to contribute to more than 7 million deaths worldwide each year and contributes to the development of atherosclerotic lesions that lead to myocardial infarction and stroke. While lifestyle modifications (diet, exercise, weight loss) and pharmacotherapy have been proven to be effective in the treatment of hypertension, as many as half of patients have uncontrolled BP and remain at risk for elevated cardiovascular morbidity and mortality. The main physiologic targets for interventional treatment include alteration of blood flow to the kidney, activation of the carotid baroreflex system, and modification of the renal sympathetic nervous system. The results of prior studies and new studies of interventional treatments of resistant hypertension are covered in this review.
高血压被认为是导致全球每年超过 700 万人死亡的罪魁祸首，它会导致动脉粥样硬化病变，进而导致心肌梗死和中风。虽然生活方式的改变（饮食、运动、减肥）和药物治疗已被证明对高血压的治疗有效，但多达一半的患者血压控制不佳，仍然存在心血管发病率和死亡率升高的风险。介入治疗的主要生理目标包括改变肾血流量、激活颈动脉压力反射系统和改变肾交感神经系统。本综述涵盖了先前研究和新的抗高血压介入治疗研究的结果。
