Arrabal-Polo Miguel Angel, Arrabal-Martin Miguel, Arias-Santiago Salvador
Department of Urology, San Cecilio University Hospital, Granada, Spain.
Korean J Urol. 2013 Mar;54(3):177-82. doi: 10.4111/kju.2013.54.3.177. Epub 2013 Mar 15.
The target of our work was to study several biochemical parameters in phospho-calcic and bone metabolism in blood and urine and the bone mineral density of women with recurrent calcium nephrolithiasis.
We conducted a cross-sectional study with a control group of 85 women divided into 3 groups: group 1 consisted of 25 women without a history of nephrolithiasis, group 2 consisted of 35 women with only one episode of calcium nephrolithiasis, and group 3 consisted of 25 women with a history of recurrent calcium nephrolithiasis. Blood and urine biochemical study was performed, including markers related to lithiasis, and a bone mineral density study was done by use of bone densitometry.
Patients in group 3 showed statistically significantly elevated calciuria (15.4 mg/dL), fasting calcium/creatinine ratio (0.14), and 24-hour calcium/creatinine ratio (0.21) compared with groups 1 and 2. Moreover, this group of women with recurrent calcium nephrolithiasis had significantly elevated values of beta-crosslaps, a bone resorption marker, compared with groups 1 and 2 (p=0.000) and showed more bone mineral density loss than did these groups.
Recurrent calcium nephrolithiasis in women has a significant association with bone mineral density loss and with values of calciuria, both fasting and 24-hour.
我们研究的目标是检测复发性钙肾结石女性患者血液和尿液中钙磷代谢及骨代谢的多项生化参数，以及骨密度。
我们进行了一项横断面研究，对照组为85名女性，分为3组：第1组由25名无肾结石病史的女性组成，第2组由35名仅有一次钙肾结石发作的女性组成，第3组由25名有复发性钙肾结石病史的女性组成。进行了血液和尿液生化研究，包括与结石形成相关的标志物，并通过骨密度测定法进行了骨密度研究。
与第1组和第2组相比，第3组患者的尿钙（15.4毫克/分升）、空腹钙/肌酐比值（0.14）和24小时钙/肌酐比值（0.21）在统计学上显著升高。此外，与第1组和第2组相比，这组复发性钙肾结石女性的骨吸收标志物β-交联羧基末端肽值显著升高（p = 0.000），且骨密度损失比这两组更多。
女性复发性钙肾结石与骨密度损失以及空腹和24小时尿钙值显著相关。
