Philips Technologie GmbH, Innovative Technologies, Research Laboratories, Hamburg, Germany.
J Magn Reson Imaging. 2013 Aug;38(2):496-503. doi: 10.1002/jmri.24041. Epub 2013 Mar 22.
In three example patients suffering from internal carotid artery occlusion, intracranial steno-occlusive disease, and symptomatic arteriovenous malformation (AVM), a new method named superselective pseudo-continuous arterial spin labeling (pCASL) was used in addition to clinical routine measurements. The capabilities of this method are demonstrated to gain important information in diagnosis, risk analysis, and treatment monitoring that are neither accessible by digital subtraction angiography nor by existing selective arterial spin labeling methods and thus to propose future applications in clinical routine. In all cases superselective pCASL enabled the assessment of tissue viability and of territorial brain perfusion at different levels starting from major brain feeding vessels to collateral circulation at the level of the Circle of Willis to even distal branching arteries. This made it possible to estimate the contribution of an extracranial-intracranial bypass to the brain perfusion; to depict individual arteries to important functional brain areas; to identify en-passant feeding vessels of an AVM and to track possible changes in their perfusion territories after intervention.
在 3 例患有颈内动脉闭塞、颅内狭窄性闭塞性疾病和症状性动静脉畸形 (AVM) 的患者中，除了临床常规测量外，还使用了一种名为超选择性假性连续动脉自旋标记 (pCASL) 的新方法。该方法的功能被证明可以在诊断、风险分析和治疗监测中获得重要信息，这些信息既无法通过数字减影血管造影获得，也无法通过现有的选择性动脉自旋标记方法获得，因此可以提出在临床常规中的未来应用。在所有情况下，超选择性 pCASL 都能够评估组织活力和从主要脑供血血管到大脑中膜的侧支循环，甚至到远端分支动脉的不同水平的区域性脑灌注。这使得评估颅外-颅内旁路对脑灌注的贡献成为可能；描绘出重要功能脑区的个别动脉；识别 AVM 的过路供血血管，并在干预后追踪其灌注区的可能变化。
