ADAM 和 ADAMTS 家族蛋白及其在结直肠癌发病机制中的作用。
ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis.
机构信息
Department of Genetics, Wroclaw Medical University, Wroclaw, Poland.
出版信息
BMB Rep. 2013 Mar;46(3):139-50. doi: 10.5483/bmbrep.2013.46.3.176.
The ADAM and ADAMTS families, also called adamalysins belong to an important group of extracellular matrix proteins. The ADAMs family belong to both the transmembrane and secreted proteins, while ADAMTS family only contains secreted forms. Adamalysins play an important role in the cell phenotype regulation via their activities in signaling pathways, cell adhesion and migration. The human proteome contains 21 ADAM, and 19 ADAMTS proteins, which are involved in extracellular matrix remodeling, shedding of various substrates such as: adhesion ligands, growth factors, their receptors and diverse cytokines. Recent studies provide evidence that adamalysins play a crucial role in colorectal cancer (CRC) etiopathogenesis. It seems possible that adamalysins might be used as CRC prediction markers or potential pharmaceutical targets.
ADAM 和 ADAMTS 家族，也称为解整合素金属蛋白酶，属于细胞外基质蛋白的一个重要亚群。ADAM 家族属于跨膜蛋白和分泌蛋白，而 ADAMTS 家族仅包含分泌形式。解整合素金属蛋白酶通过在信号通路、细胞黏附和迁移中的活性，在细胞表型调控中发挥重要作用。人类蛋白质组包含 21 种 ADAM 和 19 种 ADAMTS 蛋白，它们参与细胞外基质重塑、各种底物（如黏附配体、生长因子、其受体和多种细胞因子）的脱落。最近的研究证据表明，解整合素金属蛋白酶在结直肠癌（CRC）的发病机制中起着至关重要的作用。似乎有可能将解整合素金属蛋白酶用作 CRC 的预测标志物或潜在的药物靶点。
Zotero 插件