Elmas Ahmet Taner, Tabel Yılmaz, Elmas Ozlem Nalbantoğlu
Department of Pediatric Nephrology, Faculty of Medicine, University of Inonu .
J Matern Fetal Neonatal Med. 2013 Oct;26(15):1474-8. doi: 10.3109/14767058.2013.789844. Epub 2013 Apr 22.
The aim of this study is to determine the reference values of serum Cystatin C (CysC) and CysC-based estimated glomerular filtration rate (GFR) on the 3rd and 30th day of life in comparison with serum creatinine (Cr) and Cr-based estimated GFR.
This prospective study was performed on 52 preterm neonates whose gestational ages were between 28 and 34 weeks. Preterm neonates were divided into three groups according to the gestational age as follows: gestational week of 28-29 (group 1), gestational week of 30-32 (group 2) and gestational week of 33-34 (group 3). Blood samples were obtained on the 3rd and the 30th days of life. CysC was determined by particle-enhanced nephelometric immunoassay.
The group 1 preterm neonates have higher CysC values (1.34 ± 0.1 mg/L) on the 3rd day of life than the group 2 (1.28 ± 0.2 mg/L) and the group 3 (1.24 ± 0.2 mg/L) but the differences were not significant (p > 0.05, for each). CysC values were independent of gestational age, birth weight and gender (p > 0.05, for each). No correlation was found between CysC and Cr on the 3rd day of life (p > 0.05).
CysC is regarded as an alternative for assessing the renal function in preterm neonates.
本研究旨在确定出生第3天和第30天血清胱抑素C（CysC）及基于CysC的估计肾小球滤过率（GFR）的参考值，并与血清肌酐（Cr）及基于Cr的估计GFR进行比较。
本前瞻性研究对52例胎龄在28至34周之间的早产儿进行。根据胎龄将早产儿分为三组，如下：28 - 29孕周（第1组）、30 - 32孕周（第2组）和33 - 34孕周（第3组）。在出生第3天和第30天采集血样。采用颗粒增强散射免疫比浊法测定CysC。
第1组早产儿出生第3天的CysC值（1.34±0.1mg/L）高于第2组（1.28±0.2mg/L）和第3组（1.24±0.2mg/L），但差异无统计学意义（每组p>0.05）。CysC值与胎龄、出生体重和性别无关（每组p>0.05）。出生第3天CysC与Cr之间无相关性（p>0.05）。
CysC可作为评估早产儿肾功能的替代指标。
