Division of Neonatology, Samsun Maternity and Child Health Hospital, Samsun, Turkey.
Acta Paediatr. 2013 Jan;102(1):e4-7. doi: 10.1111/apa.12041.
To determine reference values for cystatin C (CysC) and its correlation with creatinine (Cr), gestational age, birthweight and maternal Cr status in very low-birthweight (VLBW) preterm infants.
The study included 113 VLBW premature infants (<1500 g) of ≤ 32 gestational week. Serum Cr and CysC of the infant and serum Cr of the mother were analysed.
The mean level of CysC was 1.77 ± 0.38 mg/L on day 1 and 1.61 ± 0.37 mg/L on day 3, and the decrease was statistically significant. There was a significant correlation only between maternal Cr and first-day Cr values and negative correlations between Cr and gestational age and birthweight on third day. Creatinine was not correlated with CysC both on day 1 (r = -0.077, p = 0.417) and day 3 (r = 0.132, p = 0.164).
Here, we report the reference ranges for CysC and Cr on first and third day in VLBW infants. CysC concentrations significantly decrease by day 3 compared with day 1 and are independent of gestational week, birthweight and maternal renal function status in VLBW preterm infants.
确定极低出生体重（VLBW）早产儿胱抑素 C（CysC）及其与肌酐（Cr）、胎龄、出生体重和产妇 Cr 状态的参考值。
本研究纳入了 113 名胎龄≤32 周、出生体重≤1500g 的 VLBW 早产儿。分析了婴儿血清 Cr 和 CysC 及母亲血清 Cr。
第 1 天和第 3 天 CysC 的平均水平分别为 1.77±0.38mg/L 和 1.61±0.37mg/L，下降有统计学意义。仅在第 1 天发现产妇 Cr 与 Cr 值之间存在显著相关性，第 3 天 Cr 与胎龄和出生体重之间存在负相关。第 1 天（r=-0.077，p=0.417）和第 3 天（r=0.132，p=0.164）Cr 与 CysC 均无相关性。
本研究报道了 VLBW 婴儿第 1 天和第 3 天 CysC 和 Cr 的参考范围。与第 1 天相比，第 3 天 CysC 浓度显著下降，且在 VLBW 早产儿中，CysC 浓度独立于胎龄、出生体重和产妇肾功能状态。
