全反式维甲酸与急性早幼粒细胞白血病的晚期复发：北美协作组 I0129 研究的极长期随访结果。
All-trans retinoic acid and late relapses in acute promyelocytic leukemia: very long-term follow-up of the North American Intergroup Study I0129.
机构信息
Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.
出版信息
Leuk Res. 2013 Jul;37(7):795-801. doi: 10.1016/j.leukres.2013.03.001. Epub 2013 Mar 23.
Abstract
We report a long-term follow-up (median 11.8 years) of the First North American Intergroup Study. 379 patients were randomized to induction with ATRA or to chemotherapy. All complete responders (CR) received consolidation chemotherapy, then randomized to 1 year ATRA or observation. 245 patients received ATRA sometime during the study: 195 (80%) achieved a CR. Nine (4.6%) relapsed late (>3 years from CR), the last occurred after 4.6 years; 7 of them were still alive after 5.5-15 years. In APL patients, late relapses are uncommon, and those who sustain CR >5 years can be considered cured.
摘要
我们报告了第一北美国际协作组研究的长期随访（中位数 11.8 年）。379 名患者被随机分为 ATRA 诱导组或化疗组。所有完全缓解者（CR）均接受巩固化疗，然后随机接受 1 年 ATRA 或观察。245 名患者在研究期间接受了 ATRA：195 名（80%）达到了 CR。9 名（4.6%）晚期复发（CR 后>3 年），最后一次复发发生在 4.6 年后；7 人在 5.5-15 年后仍存活。在 APL 患者中，晚期复发并不常见，那些持续 CR>5 年的患者可被视为治愈。
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