Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Leuk Res. 2013 Sep;37(9):1004-9. doi: 10.1016/j.leukres.2013.05.007. Epub 2013 Jun 14.
We hypothesized that the high early death rate (EDR) due to bleeding in acute promyelocytic leukemia (APL) is in part attributable to delays in all- trans retinoic acid (ATRA). We conducted a retrospective analysis of the timing of ATRA administration. 204 consecutive patients with newly diagnosed APL between 1992 and 2009 were identified. The EDR was 11%. 44% of early deaths occurred in the first week. Hemorrhage accounted for 61% of early deaths. ATRA was ordered the day APL was suspected in 31% of patients. Delays in ATRA administration led to increases in the percentage of early deaths from hemorrhage.
我们假设，急性早幼粒细胞白血病（APL）出血导致的高早期死亡率（EDR）部分归因于全反式维甲酸（ATRA）的延迟使用。我们对 ATRA 给药时间进行了回顾性分析。1992 年至 2009 年间共确诊 204 例新诊断的 APL 患者。EDR 为 11%。44%的早期死亡发生在第一周。出血导致 61%的早期死亡。在 31%的患者中，APL 被怀疑的当天就开了 ATRA。ATRA 给药的延迟导致因出血导致的早期死亡百分比增加。
