Chen Yijing, Deng Chunyu, Kuang Sujuan, Ma Jue, Zhao Guodong, Zhang Guangyan, Cui Jianxiu
Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2013 Mar;33(3):360-4.
To investigate the reactivity of intrapulmonary arterial rings to vasoactive substances as thromboxane A2 and endothelin-1 in patients with chronic obstructive pulmonary disease (COPD).
Intrapulmonary arterial rings isolated from patients with normal lung function and COPD were mounted in a Multi Myograph system to determine the reactivity of the intrapulmonary arterial rings to 60 mmol/L KCl, thromboxane A2 analogue U46619 and endothelin-1 before and after preconditioning with the COX synthase inhibitor indomethacin.
The reactivity of intrapulmonary arterial rings to U46619 and endothelin-1 was significantly decreased in patients with COPD. The reactivity to U46619 was dramatically decreased in patients with normal lung function after application of indomethacin.
The reactivity of intrapulmonary arterial rings is significantly decreased in patients with COPD.
研究慢性阻塞性肺疾病（COPD）患者肺内动脉环对血管活性物质如血栓素A2和内皮素-1的反应性。
将从肺功能正常患者和COPD患者分离出的肺内动脉环安装在多通道肌张力测定系统中，以测定在使用环氧化酶合酶抑制剂吲哚美辛预处理前后肺内动脉环对60 mmol/L氯化钾、血栓素A2类似物U46619和内皮素-1的反应性。
COPD患者肺内动脉环对U46619和内皮素-1的反应性显著降低。应用吲哚美辛后，肺功能正常患者对U46619的反应性急剧降低。
COPD患者肺内动脉环的反应性显著降低。
