Hou Zhen, Mao Yun-dong, Liu Jia-yin
Department of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
Zhonghua Fu Chan Ke Za Zhi. 2013 Jan;48(1):6-10.
To evaluate the factors associated with clinical pregnancy rate of in-vitro fertilization (IVF) in endometriosis related infertility.
Total of 326 patients with endometriosis related infertility undergoing IVF between January 2007 and December 2011 were studied in Department of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, retrospectively, which were divided into 141 cases in clinical pregnancy group and 185 cases in non-pregnancy group. Those factors including age, body mass index (BMI), basic FSH, antral follicle count (AFC), CA125 and CA199, endometriotic stage and history of surgery, stimulation scheme were analyzed by bivariate analysis and multivariable logistic regression.
(1) Pregnancy rate:total of 141 pregnant cases and 185 non-pregnant cases treated by IVF were observed, pregnancy rate was 43.2% (141/326). (2) Basic parameters: there was no statistical difference in age, BMI, basic FSH, AFC, CA125 and CA199 between clinical pregnancy group and non-pregnancy group (P > 0.05). (3) Bivariate analysis: clinical pregnancy rate of 50.0% (87/174) among patients with infertility year less than five years was significantly higher than 35.5% (54/152) in patients with more than five years. Pregnancy rate of 56.1% (46/82) in stage I-II was significantly higher than 42.5% (79/186) in stage III-IV. Pregnancy rate of 46.6% (125/268) with history of surgery was significantly higher than 27.6% (16/58) with no history of surgery (P < 0.05). Pregnancy rate of 48.2% (79/164) in long-term scheme was higher than 38.3% (62/162) in short-term scheme, but there was no significant difference (P = 0.075). (4) Multivariable logistic regression: clinical pregnancy rate of infertility year with less than 5 years, stage I-II, history of surgery proved stage I-II and stage III-IV was significantly higher compared with infertility year more than 5 years, stage III-IV and no history of surgery respectively (adjusted OR and 95%CI: 2.003, 1.263 - 3.175; 1.899, 1.110 - 3.248; 3.769, 1.802 - 7.887, P < 0.05).
Factors affecting clinical pregnancy rate of IVF in endometriosis related infertility were infertility year, stage and surgery.
评估与子宫内膜异位症相关性不孕体外受精（IVF）临床妊娠率相关的因素。
回顾性研究2007年1月至2011年12月在南京医科大学第一附属医院生殖医学科接受IVF治疗的326例子宫内膜异位症相关性不孕患者，分为临床妊娠组141例和未妊娠组185例。通过双变量分析和多变量逻辑回归分析年龄、体重指数（BMI）、基础促卵泡激素（FSH）、窦卵泡计数（AFC）、CA125和CA199、子宫内膜异位症分期及手术史、促排卵方案等因素。
（1）妊娠率：观察IVF治疗的141例妊娠患者和185例未妊娠患者，妊娠率为43.2%（141/326）。（2）基础参数：临床妊娠组与未妊娠组在年龄、BMI、基础FSH、AFC、CA125和CA199方面无统计学差异（P>0.05）。（3）双变量分析：不孕年限小于5年的患者临床妊娠率为50.0%（87/174），显著高于不孕年限大于5年患者的35.5%（54/152）。I-II期患者妊娠率为56.1%（46/82），显著高于III-IV期的42.5%（79/186）。有手术史患者的妊娠率为46.6%（125/268），显著高于无手术史患者的27.6%（16/58）（P<0.05）。长期方案妊娠率为48.2%（79/164），高于短期方案的38.3%（62/162），但无显著差异（P=0.075）。（4）多变量逻辑回归：不孕年限小于5年、I-II期、有手术史，与不孕年限大于5年、III-IV期、无手术史相比，临床妊娠率显著更高（校正比值比及95%可信区间：2.003，1.263 - 3.175；1.899，1.110 - 3.248；3.769，1.802 - 7.887，P<0.05）。
影响子宫内膜异位症相关性不孕IVF临床妊娠率的因素为不孕年限、分期及手术。
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