Jensen A E, Reikvam A, Asberg A
Department of Clinical Chemistry, Central Hospital of Sogn og Fjordane, Førde, Norway.
Scand J Clin Lab Invest. 1990 May;50(3):285-9. doi: 10.3109/00365519009091580.
Diagnostic efficiency of lactate dehydrogenase isoenzymes were studied in 117 consecutive patients admitted with some symptoms of acute myocardial infarction. The results of lactate dehydrogenase isoenzyme tests were not available to the physicians, who diagnosed the patients according to criteria based on clinical symptoms, electrocardiographic findings and changes in three serum enzymes. Acute myocardial infarction was diagnosed in 41 patients. The diagnostic efficiency of lactate dehydrogenase isoenzyme 1 and the various ratios between this and the other isoenzymes were compared using receiver operating characteristic curves and logistic discriminant analysis. Lactate dehydrogenase isoenzyme 1 was the best parameter on the second day after admission. On that day, calculating the various ratios between isoenzyme 1 and the other isoenzymes did not improve discrimination.
对117例因急性心肌梗死某些症状入院的连续患者进行了乳酸脱氢酶同工酶的诊断效率研究。医生在诊断患者时无法获得乳酸脱氢酶同工酶检测结果，他们根据基于临床症状、心电图表现和三种血清酶变化的标准进行诊断。41例患者被诊断为急性心肌梗死。使用受试者工作特征曲线和逻辑判别分析比较了乳酸脱氢酶同工酶1的诊断效率以及该同工酶与其他同工酶之间的各种比率。入院后第二天，乳酸脱氢酶同工酶1是最佳参数。在那一天，计算同工酶1与其他同工酶之间的各种比率并没有提高诊断的区分度。
