Nilsson L, Bagge L, Nyström S O
Department of Thoracic Surgery, University Hospital, Uppsala, Sweden.
Scand J Thorac Cardiovasc Surg. 1990;24(1):65-9. doi: 10.3109/14017439009101826.
Blood cell trauma and postoperative bleeding were studied in 96 patients following coronary artery bypass grafting, with bubble oxygenator used in 47 cases and membrane oxygenator in 49. The haemocompatibility of membrane oxygenators was superior to that of the bubble type, as reflected by less haemolysis, better preservation of platelet function, less release of betathromboglobulin and less degranulation of neutrophil granulocytes. Coronary suction contributed to haemolysis, but did not affect platelet or granulocyte function. Fibrinolysis, postoperative blood loss and need for blood transfusion did not differ between the bubble and membrane oxygenator groups.
对96例行冠状动脉搭桥术的患者的血细胞损伤和术后出血情况进行了研究,其中47例使用鼓泡式氧合器,49例使用膜式氧合器。膜式氧合器的血液相容性优于鼓泡式氧合器,表现为溶血较少、血小板功能保存较好、β-血栓球蛋白释放较少以及中性粒细胞脱颗粒较少。冠状动脉吸引会导致溶血,但不影响血小板或粒细胞功能。鼓泡式氧合器组和膜式氧合器组在纤维蛋白溶解、术后失血量及输血需求方面无差异。