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家族性地中海热中对氧磷酶-1、丙二醛和平均血小板体积与动脉粥样硬化标志物的关系:一项观察性研究

Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study.

作者信息

Karakurt Arıtürk Özlem, Üreten Kemal, Sarı Münevver, Yazıhan Nuray, Ermiş Ezgi, Ergüder İmge

机构信息

Clinic of Cardiology, Balıkesir State Hospital, Balıkesir-Turkey.

出版信息

Anadolu Kardiyol Derg. 2013 Jun;13(4):357-62. doi: 10.5152/akd.2013.103. Epub 2013 Mar 26.

Abstract

OBJECTIVE

There are many studies demonstrating deteriorated ventricle and endothelium functions in familial Mediterranean fever (FMF) patients. As FMF is an autoinflammatory disease with an ongoing inflammatory activity and inflammation plays an important role in the development and progression of atherosclerosis in some of the rheumatic diseases, we aimed to investigate the early markers of atherosclerosis in patients with FMF by the measurements of serum paraoxonase-1 (PON-1) activity, mean platelet volume (MPV) and malondialdehyde (MDA) level.

METHODS

This study is a cross-sectional, observational study. Forty consecutive patients with FMF and twenty healthy volunteers were selected to form the study population. The diagnosis of FMF was based on Tel-Hashomer criteria. Serum PON-1 activity, MPV and MDA level were determined to examine their association with FMF. Student's t-test, Mann-Whitney U test, Pearson correlation analysis were used for statistical analysis.

RESULTS

The mean PON-1 activity in FMF patients was significantly lower than in the healthy population (141.46±38.29 vs. 179.62±10.73 U/l, p<0.01). Serum MDA levels were the same between the groups (1.08±0.66 vs. 1.08±0.33 nmol/mL, p=0.99). MPV was higher in FMF patients than in the control l group (8.87±0.99 vs. 8.22±0.45 fl, p=0.04). PON, MPV and MDA levels were the same in FMF patients with acute attack and attack -free period.

CONCLUSION

Our results show that PON-1 activity is lower in patients with FMF. Reduced PON-1 activity and increased MPV, independent of the oxidative stress status of these patients, may lead to increased atherosclerotic propensity in FMF.

摘要

目的

有许多研究表明家族性地中海热(FMF)患者存在心室和内皮功能恶化。由于FMF是一种具有持续炎症活动的自身炎症性疾病,且炎症在某些风湿性疾病的动脉粥样硬化发展和进程中起重要作用,我们旨在通过测量血清对氧磷酶-1(PON-1)活性、平均血小板体积(MPV)和丙二醛(MDA)水平来研究FMF患者动脉粥样硬化的早期标志物。

方法

本研究为横断面观察性研究。连续选取40例FMF患者和20名健康志愿者组成研究人群。FMF的诊断基于Tel-Hashomer标准。测定血清PON-1活性、MPV和MDA水平,以检验它们与FMF的关联。采用学生t检验、曼-惠特尼U检验、Pearson相关性分析进行统计学分析。

结果

FMF患者的平均PON-1活性显著低于健康人群(141.46±38.29 vs. 179.62±10.73 U/l,p<0.01)。两组间血清MDA水平相同(1.08±0.66 vs. 1.08±0.33 nmol/mL,p=0.99)。FMF患者的MPV高于对照组(8.87±0.99 vs. 8.22±0.45 fl,p=0.04)。急性发作期和无发作期的FMF患者的PON、MPV和MDA水平相同。

结论

我们的结果表明FMF患者的PON-1活性较低。PON-1活性降低和MPV升高,与这些患者的氧化应激状态无关,可能导致FMF患者动脉粥样硬化倾向增加。

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