Makay Balahan, Türkyilmaz Zeynep, Unsal Erbil
Department of Pediatrics, Division of Pediatric Immunology and Rheumatology, Dokuz Eylül University Hospital, Balçova 35340, Izmir, Turkey.
Clin Rheumatol. 2009 Aug;28(8):975-8. doi: 10.1007/s10067-009-1148-5. Epub 2009 Mar 13.
Familial Mediterranean fever (FMF) is the most common inherited periodic fever syndrome characterized by recurrent episodes of serositis. Recently, a few studies have suggested that FMF is related to increased risk of atherosclerosis. Mean platelet volume (MPV) is a marker of platelet activation. Larger platelets are associated with increased atherosclerosis risk. The aim of the study is to evaluate levels of MPV in pediatric FMF patients during and between attacks. The study consisted of 48 patients during an attack (group 1), 63 patients in attack-free period (at least 2 weeks after an attack, group 2), and 49 healthy controls (group 3). Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count (PLT), and MPV levels were retrospectively recorded from the computerized patient database. Mean platelet volume was significantly lower in FMF patients during attack than in attack-free period (p = 0.00); however, there was no difference among attack-free patients and healthy controls (p = 0.38). The mean platelet counts of FMF patients during attack were higher than the healthy controls (p = 0.02). There was an inverse correlation between MPV and mean PLT in the attack-free period (r = -446, p = 0.01). This study suggests that an early atherosclerosis marker, MPV, is not elevated in pediatric FMF patients on colchicine treatment.
家族性地中海热（FMF）是最常见的遗传性周期性发热综合征，其特征为反复发作的浆膜炎。最近，一些研究表明，FMF与动脉粥样硬化风险增加有关。平均血小板体积（MPV）是血小板活化的标志物。较大的血小板与动脉粥样硬化风险增加相关。本研究的目的是评估小儿FMF患者发作期间及发作间期的MPV水平。该研究包括48例发作期患者（第1组）、63例无发作期患者（发作后至少2周，第2组）和49例健康对照者（第3组）。从计算机化患者数据库中回顾性记录红细胞沉降率、C反应蛋白、白细胞计数、血小板计数（PLT）和MPV水平。FMF患者发作期的平均血小板体积显著低于无发作期（p = 0.00）；然而，无发作期患者与健康对照者之间无差异（p = 0.38）。FMF患者发作期的平均血小板计数高于健康对照者（p = 0.02）。在无发作期，MPV与平均PLT之间呈负相关（r = -446，p = 0.01）。本研究表明，在接受秋水仙碱治疗的小儿FMF患者中，早期动脉粥样硬化标志物MPV并未升高。
