Department of Internal Medicine, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
Eur J Intern Med. 2012 Oct;23(7):661-4. doi: 10.1016/j.ejim.2012.04.007. Epub 2012 May 3.
Many studies have shown that subclinical inflammation persisted during remission period of Familial Mediterranean Fever (FMF) patients but long term effects of subclinical inflammation in these patients aren't clearly known. Besides, a few of the recent studies revealed that risk of atherosclerosis had increased in FMF patients. β-Thromboglobulin (β-TG) is considered as a sensitive marker of platelet activation. In this study Mean Platelet Volume (MPV) and β-TG levels were evaluated in FMF patients.
Following the Local Ethics Committee's consent, 25 FMF patients were included in the study. Twenty eight age and sex matched healthy volunteers were recruited as a control group. Lipid profile, inflammatory parameters, hemogram, β-TG, MPV were assessed. Statistical analysis was performed with SPSS for Windows 16.00.
Group I consisted of 25 FMF cases (16 females, 9 males; mean age: 35.72 ± 12.34 years), Group II consisted of 28 cases (22 females, 6 males; mean age 31.78 ± 10.31 years). There was no statistically significant difference between the groups in terms of age and gender distribution, smoking status, total cholesterol, triglyceride, LDL and MPV (p>0.05). HDL levels were found to be statistically lower in Group I (p:0.04). Median β-TG levels was significantly higher in Group II than Group I (129.50 (range:372.00) ng/mL versus 104.00 (range:212.80) ng/mL respectively; p:0.03).
In this study MPV and β-TG were evaluated for FMF cases and healthy controls, β-TG levels were found significantly lower among patients; we hypothesized that this difference may have resulted from the effect of colchicine use on platelet functions.
许多研究表明,家族性地中海热(FMF)患者在缓解期仍存在亚临床炎症,但这些患者的亚临床炎症的长期影响尚不清楚。此外,最近的一些研究表明,FMF 患者患动脉粥样硬化的风险增加。β-血栓球蛋白(β-TG)被认为是血小板激活的敏感标志物。在这项研究中,我们评估了 FMF 患者的平均血小板体积(MPV)和β-TG 水平。
在获得当地伦理委员会同意后,我们纳入了 25 例 FMF 患者作为研究对象。并招募了 28 名年龄和性别相匹配的健康志愿者作为对照组。评估了血脂谱、炎症参数、血常规、β-TG、MPV。使用 SPSS for Windows 16.00 进行统计分析。
组 I 由 25 例 FMF 患者(16 名女性,9 名男性;平均年龄:35.72 ± 12.34 岁)组成,组 II 由 28 例患者(22 名女性,6 名男性;平均年龄 31.78 ± 10.31 岁)组成。两组在年龄和性别分布、吸烟状况、总胆固醇、甘油三酯、LDL 和 MPV 方面无统计学差异(p>0.05)。组 I 的高密度脂蛋白水平显著较低(p:0.04)。组 II 的β-TG 中位数显著高于组 I(129.50(范围:372.00)ng/mL 与 104.00(范围:212.80)ng/mL 相比;p:0.03)。
在这项研究中,我们评估了 FMF 病例和健康对照组的 MPV 和β-TG,发现患者的β-TG 水平显著较低;我们假设这种差异可能是由于秋水仙碱对血小板功能的影响所致。